======= KEL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KEL
  * **<color #00a2e8>Official Name</color>**: Kell metallo-endopeptidase (Kell blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3792|3792]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23276|P23276]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KEL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KEL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613883|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. {ECO:0000269|PubMed:10438732}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M13|
|Peptidase M13 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular magnesium ion homeostasis|
|regulation of axon diameter|
|magnesium ion homeostasis|
|regulation of cell projection size|
|skeletal muscle fiber development|
|negative regulation of potassium ion transmembrane transport|
|myotube cell development|
|vasoconstriction|
|negative regulation of potassium ion transport|
|negative regulation of blood vessel diameter|
|myotube differentiation|
|muscle fiber development|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|metalloendopeptidase activity|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|negative regulation of transmembrane transport|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|striated muscle cell development|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|negative regulation of ion transport|
|muscle cell development|
|vascular process in circulatory system|
|regulation of cell size|
|regulation of axonogenesis|
|striated muscle cell differentiation|
|muscle cell differentiation|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|regulation of cell morphogenesis involved in differentiation|
|regulation of cation transmembrane transport|
|regulation of cellular component size|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of neurogenesis|
|cellular homeostasis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|proteolysis|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|tissue development|
|regulation of cell differentiation|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9446
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KEL Expression in NALM6 Cells: -0.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>