======= KHK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KHK
  * **<color #00a2e8>Official Name</color>**: ketohexokinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3795|3795]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50053|P50053]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KHK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KHK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614058|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. {ECO:0000269|PubMed:12941785}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PfkB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ketohexokinase activity|
|carbohydrate kinase activity|
|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|
|fructose catabolic process|
|response to disaccharide|
|response to sucrose|
|glyceraldehyde-3-phosphate metabolic process|
|response to fructose|
|fructose metabolic process|
|carbohydrate phosphorylation|
|regulation of glycogen metabolic process|
|regulation of polysaccharide metabolic process|
|hexose catabolic process|
|response to zinc ion|
|cellular aldehyde metabolic process|
|monosaccharide catabolic process|
|regulation of glucose metabolic process|
|carbohydrate catabolic process|
|response to glucose|
|regulation of cellular carbohydrate metabolic process|
|response to hexose|
|response to monosaccharide|
|hexose metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular carbohydrate metabolic process|
|response to carbohydrate|
|monosaccharide metabolic process|
|regulation of carbohydrate metabolic process|
|response to insulin|
|response to metal ion|
|response to peptide hormone|
|regulation of small molecule metabolic process|
|small molecule catabolic process|
|response to peptide|
|carbohydrate metabolic process|
|response to inorganic substance|
|organophosphate metabolic process|
|response to hormone|
|response to organonitrogen compound|
|carbohydrate derivative metabolic process|
|response to nitrogen compound|
|phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.77|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.76|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15366
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KHK Expression in NALM6 Cells: 2.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>