======= KIAA0391 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRORP
  * **<color #00a2e8>Official Name</color>**: protein only RNase P catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9692|9692]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15091|O15091]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA0391&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA0391|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609947|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:25953853}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial tRNA 5-end processing|
|mitochondrial ribonuclease P complex|
|mitochondrial RNA 5-end processing|
|mitochondrial tRNA methylation|
|mitochondrial tRNA modification|
|mitochondrial RNA modification|
|ribonuclease P activity|
|tRNA 5-leader removal|
|mitochondrial tRNA processing|
|tRNA 5-end processing|
|tRNA threonylcarbamoyladenosine metabolic process|
|mitochondrial RNA processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|tRNA methylation|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|RNA methylation|
|tRNA modification|
|tRNA processing|
|mitochondrial gene expression|
|RNA phosphodiester bond hydrolysis|
|RNA modification|
|tRNA metabolic process|
|macromolecule methylation|
|nucleic acid phosphodiester bond hydrolysis|
|methylation|
|mitochondrial matrix|
|ncRNA processing|
|ncRNA metabolic process|
|RNA processing|
|mitochondrion|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|-3.15|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.36|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.25|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.8|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.75|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.75|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.72|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.72|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.79|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.81|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.84|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.88|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.9|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.05|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.07|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.09|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.5|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.66|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.78|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.685|
|[[:human genes:m:mrps34|MRPS34]]|0.672|
|[[:human genes:m:mrps14|MRPS14]]|0.669|
|[[:human genes:m:mrps18a|MRPS18A]]|0.668|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.661|
|[[:human genes:y:yars2|YARS2]]|0.66|
|[[:human genes:r:rpusd4|RPUSD4]]|0.652|
|[[:human genes:m:mrps6|MRPS6]]|0.65|
|[[:human genes:s:selrc1|SELRC1]]|0.647|
|[[:human genes:s:sars2|SARS2]]|0.639|
|[[:human genes:d:dap3|DAP3]]|0.639|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.631|
|[[:human genes:p:pars2|PARS2]]|0.626|
|[[:human genes:m:mrps5|MRPS5]]|0.626|
|[[:human genes:m:mrpl23|MRPL23]]|0.621|
|[[:human genes:t:tars2|TARS2]]|0.619|
|[[:human genes:m:mrps16|MRPS16]]|0.614|
|[[:human genes:v:vars2|VARS2]]|0.61|
|[[:human genes:b:bcs1l|BCS1L]]|0.61|
|[[:human genes:d:dars2|DARS2]]|0.608|
|[[:human genes:g:gfm1|GFM1]]|0.608|
|[[:human genes:m:mrpl47|MRPL47]]|0.607|
|[[:human genes:t:tefm|TEFM]]|0.606|
|[[:human genes:h:hars2|HARS2]]|0.604|
|[[:human genes:n:nars2|NARS2]]|0.601|
|[[:human genes:c:cox16|COX16]]|0.597|
|[[:human genes:q:qrsl1|QRSL1]]|0.597|
|[[:human genes:d:dhrsx|DHRSX]]|0.592|
|[[:human genes:t:trub2|TRUB2]]|0.592|
|[[:human genes:m:mrps12|MRPS12]]|0.591|
|[[:human genes:r:rars2|RARS2]]|0.59|
|[[:human genes:e:ears2|EARS2]]|0.589|
|[[:human genes:m:mtpap|MTPAP]]|0.588|
|[[:human genes:s:sco2|SCO2]]|0.588|
|[[:human genes:m:mrpl53|MRPL53]]|0.587|
|[[:human genes:m:mrps21|MRPS21]]|0.585|
|[[:human genes:l:lars2|LARS2]]|0.58|
|[[:human genes:s:slc25a26|SLC25A26]]|0.579|
|[[:human genes:p:pnpt1|PNPT1]]|0.577|
|[[:human genes:m:mrps26|MRPS26]]|0.574|
|[[:human genes:r:rbfa|RBFA]]|0.574|
|[[:human genes:u:uqcr10|UQCR10]]|0.572|
|[[:human genes:m:mrps9|MRPS9]]|0.57|
|[[:human genes:m:mrps2|MRPS2]]|0.563|
|[[:human genes:m:mars2|MARS2]]|0.562|
|[[:human genes:t:tufm|TUFM]]|0.562|
|[[:human genes:g:gatc|GATC]]|0.561|
|[[:human genes:w:wbscr16|WBSCR16]]|0.56|
|[[:human genes:g:gfm2|GFM2]]|0.557|
|[[:human genes:m:mtg2|MTG2]]|0.554|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.551|
|[[:human genes:m:mrpl55|MRPL55]]|0.545|
|[[:human genes:f:fastkd5|FASTKD5]]|0.544|
|[[:human genes:m:mrps24|MRPS24]]|0.543|
|[[:human genes:m:mrp63|MRP63]]|0.541|
|[[:human genes:c:c10orf2|C10orf2]]|0.541|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.539|
|[[:human genes:a:aars2|AARS2]]|0.535|
|[[:human genes:t:trmt10a|TRMT10A]]|0.531|
|[[:human genes:c:cox17|COX17]]|0.523|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.52|
|[[:human genes:t:triap1|TRIAP1]]|0.518|
|[[:human genes:c:cox7b|COX7B]]|0.518|
|[[:human genes:f:fars2|FARS2]]|0.516|
|[[:human genes:e:elac2|ELAC2]]|0.514|
|[[:human genes:m:mrps10|MRPS10]]|0.514|
|[[:human genes:m:mrps33|MRPS33]]|0.512|
|[[:human genes:t:trmt61a|TRMT61A]]|0.512|
|[[:human genes:m:mrpl12|MRPL12]]|0.51|
|[[:human genes:m:mrps23|MRPS23]]|0.508|
|[[:human genes:c:c17orf89|C17orf89]]|0.508|
|[[:human genes:p:pdss1|PDSS1]]|0.508|
|[[:human genes:m:mrps25|MRPS25]]|0.508|
|[[:human genes:c:cox6c|COX6C]]|0.508|
|[[:human genes:c:coq3|COQ3]]|0.506|
|[[:human genes:n:ndufb11|NDUFB11]]|0.505|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.503|
|[[:human genes:m:mrpl20|MRPL20]]|0.503|
|[[:human genes:n:ndufa3|NDUFA3]]|0.503|
|[[:human genes:c:coa6|COA6]]|0.503|
|[[:human genes:m:mrpl33|MRPL33]]|0.502|
|[[:human genes:m:mrpl18|MRPL18]]|0.501|
|[[:human genes:m:mrpl36|MRPL36]]|0.499|
|[[:human genes:m:mrpl3|MRPL3]]|0.49|
|[[:human genes:p:ppa2|PPA2]]|0.49|
|[[:human genes:a:atp5d|ATP5D]]|0.49|
|[[:human genes:m:mrpl15|MRPL15]]|0.488|
|[[:human genes:a:atp5b|ATP5B]]|0.488|
|[[:human genes:d:dohh|DOHH]]|0.488|
|[[:human genes:t:thg1l|THG1L]]|0.487|
|[[:human genes:t:tomm20|TOMM20]]|0.487|
|[[:human genes:f:ftsj2|FTSJ2]]|0.486|
|[[:human genes:m:mrpl44|MRPL44]]|0.485|
|[[:human genes:d:dnlz|DNLZ]]|0.482|
|[[:human genes:c:c12orf65|C12orf65]]|0.482|
|[[:human genes:p:pgm3|PGM3]]|0.481|
|[[:human genes:l:lsm10|LSM10]]|0.48|
|[[:human genes:s:ssb|SSB]]|0.479|
|[[:human genes:m:mrps17|MRPS17]]|0.478|
|[[:human genes:c:crls1|CRLS1]]|0.478|
|[[:human genes:a:alg6|ALG6]]|0.477|
|[[:human genes:u:uap1|UAP1]]|0.477|
|[[:human genes:t:tmem242|TMEM242]]|0.476|
|[[:human genes:p:pmm2|PMM2]]|0.475|
|[[:human genes:m:mrpl42|MRPL42]]|0.474|
|[[:human genes:p:ppcs|PPCS]]|0.472|
|[[:human genes:k:kdsr|KDSR]]|0.471|
|[[:human genes:t:taz|TAZ]]|0.471|
|[[:human genes:a:atp5a1|ATP5A1]]|0.47|
|[[:human genes:t:tfam|TFAM]]|0.47|
|[[:human genes:c:chchd4|CHCHD4]]|0.47|
|[[:human genes:c:cox15|COX15]]|0.47|
|[[:human genes:p:pitrm1|PITRM1]]|0.469|
|[[:human genes:m:mrps35|MRPS35]]|0.469|
|[[:human genes:t:tmem126b|TMEM126B]]|0.467|
|[[:human genes:m:mrps11|MRPS11]]|0.467|
|[[:human genes:r:rpia|RPIA]]|0.467|
|[[:human genes:o:opa1|OPA1]]|0.467|
|[[:human genes:c:coq2|COQ2]]|0.464|
|[[:human genes:p:pet112|PET112]]|0.464|
|[[:human genes:m:mrpl34|MRPL34]]|0.464|
|[[:human genes:d:dhx30|DHX30]]|0.463|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.463|
|[[:human genes:t:tpk1|TPK1]]|0.462|
|[[:human genes:u:uqcrq|UQCRQ]]|0.461|
|[[:human genes:m:mrpl4|MRPL4]]|0.461|
|[[:human genes:m:mtif3|MTIF3]]|0.461|
|[[:human genes:t:tomm22|TOMM22]]|0.46|
|[[:human genes:f:fh|FH]]|0.457|
|[[:human genes:r:romo1|ROMO1]]|0.457|
|[[:human genes:p:polg2|POLG2]]|0.456|
|[[:human genes:m:mtg1|MTG1]]|0.455|
|[[:human genes:s:sec62|SEC62]]|0.454|
|[[:human genes:d:dpagt1|DPAGT1]]|0.454|
|[[:human genes:r:rpusd3|RPUSD3]]|0.453|
|[[:human genes:a:atic|ATIC]]|0.453|
|[[:human genes:m:mrpl39|MRPL39]]|0.452|
|[[:human genes:m:mrps7|MRPS7]]|0.451|
|[[:human genes:m:mterfd2|MTERFD2]]|0.451|
|[[:human genes:w:wars2|WARS2]]|0.451|
|[[:human genes:a:atp5o|ATP5O]]|0.451|
|[[:human genes:m:mrpl41|MRPL41]]|0.45|
|[[:human genes:m:mrpl11|MRPL11]]|0.447|
|[[:human genes:c:coa5|COA5]]|0.447|
|[[:human genes:a:aifm1|AIFM1]]|0.446|
|[[:human genes:m:minos1|MINOS1]]|0.445|
|[[:human genes:n:ndufc2|NDUFC2]]|0.443|
|[[:human genes:l:lrpprc|LRPPRC]]|0.443|
|[[:human genes:m:mipep|MIPEP]]|0.442|
|[[:human genes:c:cars2|CARS2]]|0.442|
|[[:human genes:c:cox5a|COX5A]]|0.442|
|[[:human genes:m:mrpl52|MRPL52]]|0.441|
|[[:human genes:c:coq7|COQ7]]|0.439|
|[[:human genes:c:cox11|COX11]]|0.437|
|[[:human genes:m:mrpl13|MRPL13]]|0.437|
|[[:human genes:a:atxn10|ATXN10]]|0.436|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.436|
|[[:human genes:g:gfpt1|GFPT1]]|0.436|
|[[:human genes:m:mettl17|METTL17]]|0.436|
|[[:human genes:n:ndufb5|NDUFB5]]|0.435|
|[[:human genes:c:coa3|COA3]]|0.434|
|[[:human genes:h:hccs|HCCS]]|0.433|
|[[:human genes:u:uhrf1|UHRF1]]|0.433|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.43|
|[[:human genes:n:ndufa2|NDUFA2]]|0.43|
|[[:human genes:t:tamm41|TAMM41]]|0.43|
|[[:human genes:t:tomm40|TOMM40]]|0.429|
|[[:human genes:z:zrsr2|ZRSR2]]|0.428|
|[[:human genes:t:timm8b|TIMM8B]]|0.428|
|[[:human genes:l:lsm11|LSM11]]|0.427|
|[[:human genes:c:cox6b1|COX6B1]]|0.425|
|[[:human genes:a:alg8|ALG8]]|0.424|
|[[:human genes:n:ndufv1|NDUFV1]]|0.423|
|[[:human genes:n:ndufa1|NDUFA1]]|0.422|
|[[:human genes:a:atp5sl|ATP5SL]]|0.422|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.422|
|[[:human genes:m:mrpl46|MRPL46]]|0.421|
|[[:human genes:a:alg13|ALG13]]|0.421|
|[[:human genes:a:atp5h|ATP5H]]|0.42|
|[[:human genes:t:ttc4|TTC4]]|0.417|
|[[:human genes:d:dolk|DOLK]]|0.416|
|[[:human genes:m:mrps22|MRPS22]]|0.416|
|[[:human genes:a:atp5c1|ATP5C1]]|0.415|
|[[:human genes:m:mrpl27|MRPL27]]|0.415|
|[[:human genes:p:polrmt|POLRMT]]|0.415|
|[[:human genes:n:ndufb9|NDUFB9]]|0.413|
|[[:human genes:r:rpe|RPE]]|0.413|
|[[:human genes:v:vezt|VEZT]]|0.413|
|[[:human genes:t:tmem41b|TMEM41B]]|0.411|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.411|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.41|
|[[:human genes:c:cycs|CYCS]]|0.409|
|[[:human genes:m:mbtps2|MBTPS2]]|0.408|
|[[:human genes:u:urm1|URM1]]|0.408|
|[[:human genes:p:polg|POLG]]|0.407|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.406|
|[[:human genes:p:pdcd5|PDCD5]]|0.406|
|[[:human genes:m:mrpl17|MRPL17]]|0.404|
|[[:human genes:c:cbfb|CBFB]]|0.403|
|[[:human genes:m:mrpl22|MRPL22]]|0.402|
|[[:human genes:n:ndufb6|NDUFB6]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 91/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|2/26|
|breast|8/33|
|central nervous system|4/56|
|cervix|3/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|2/21|
|liver|4/20|
|lung|14/75|
|lymphocyte|2/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 795
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA0391 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>