======= KIAA1462 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JCAD
  * **<color #00a2e8>Official Name</color>**: junctional cadherin 5 associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57608|57608]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P266|Q9P266]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA1462&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA1462|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614398|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of vascular endothelial growth factor signaling pathway|
|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|regulation of vascular endothelial growth factor signaling pathway|
|regulation of cellular response to vascular endothelial growth factor stimulus|
|positive regulation of cell migration involved in sprouting angiogenesis|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of sprouting angiogenesis|
|positive regulation of blood vessel endothelial cell migration|
|adherens junction|
|regulation of sprouting angiogenesis|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell proliferation|
|ruffle membrane|
|positive regulation of endothelial cell migration|
|regulation of endothelial cell proliferation|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|cell-cell junction|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|regulation of epithelial cell migration|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|perinuclear region of cytoplasm|
|regulation of MAPK cascade|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13740
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA1462 Expression in NALM6 Cells: 1.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>