======= KIF18A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF18A
  * **<color #00a2e8>Official Name</color>**: kinesin family member 18A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81930|81930]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NI77|Q8NI77]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF18A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF18A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611271|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tubulin-dependent ATPase activity|
|mitotic spindle astral microtubule|
|kinetochore microtubule|
|seminiferous tubule development|
|mitotic spindle midzone|
|microtubule plus-end binding|
|microtubule depolymerization|
|ATP-dependent microtubule motor activity, plus-end-directed|
|protein depolymerization|
|cellular response to estradiol stimulus|
|mitotic metaphase plate congression|
|male meiotic nuclear division|
|microtubule polymerization or depolymerization|
|kinesin complex|
|metaphase plate congression|
|microtubule motor activity|
|establishment of chromosome localization|
|chromosome localization|
|caveola|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|kinetochore|
|ruffle|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|mitotic sister chromatid segregation|
|male gonad development|
|development of primary male sexual characteristics|
|response to estradiol|
|cellular protein complex disassembly|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic nuclear division|
|microtubule cytoskeleton|
|male sex differentiation|
|microtubule organizing center|
|meiotic cell cycle process|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|regulation of microtubule cytoskeleton organization|
|antigen processing and presentation of peptide antigen|
|gonad development|
|antigen processing and presentation|
|development of primary sexual characteristics|
|nuclear chromosome segregation|
|regulation of microtubule-based process|
|meiotic cell cycle|
|ATPase activity|
|microtubule binding|
|protein-containing complex disassembly|
|sex differentiation|
|actin binding|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|organelle fission|
|microtubule|
|cellular process involved in reproduction in multicellular organism|
|establishment of organelle localization|
|Golgi vesicle transport|
|cellular component disassembly|
|reproductive structure development|
|reproductive system development|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|cellular response to lipid|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|male gamete generation|
|organelle localization|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|developmental process involved in reproduction|
|microtubule-based process|
|mitotic cell cycle|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|multi-organism reproductive process|
|cell cycle process|
|cellular response to oxygen-containing compound|
|chromosome organization|
|cytoskeleton organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|peptide transport|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-5.81|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-4.6|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-4.36|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-4.14|
|[[:results:exp453|B02 10μM R08 exp453]]|-3.32|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-3.31|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.89|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.73|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.65|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.6|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.52|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.31|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.14|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.13|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.12|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.11|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.11|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.1|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.07|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.02|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.96|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.95|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.88|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:ska1|SKA1]]|0.533|
|[[:human genes:a:aspm|ASPM]]|0.42|
|[[:human genes:a:actr1b|ACTR1B]]|0.416|
|[[:human genes:r:rbbp4|RBBP4]]|0.416|
|[[:human genes:g:gak|GAK]]|0.414|
|[[:human genes:a:aar2|AAR2]]|0.413|
|[[:human genes:a:actr1a|ACTR1A]]|0.408|
|[[:human genes:k:kif15|KIF15]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 524/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|13/28|
|bone|17/26|
|breast|21/33|
|central nervous system|45/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|18/21|
|liver|17/20|
|lung|49/75|
|lymphocyte|14/16|
|ovary|17/26|
|pancreas|20/24|
|peripheral nervous system|14/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2932
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF18A Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>