======= KIF1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF1B
  * **<color #00a2e8>Official Name</color>**: kinesin family member 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23095|23095]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60333|O60333]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605995|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|Kinesin|
|FHA|
|DUF3694|
|KIF1B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to rotenone|
|anterograde neuronal dense core vesicle transport|
|retrograde neuronal dense core vesicle transport|
|dense core granule localization|
|dense core granule cytoskeletal transport|
|dense core granule transport|
|neuron-neuron synaptic transmission|
|secretory granule localization|
|response to insecticide|
|retrograde axonal transport|
|establishment of mitochondrion localization, microtubule-mediated|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization|
|ATP-dependent microtubule motor activity, plus-end-directed|
|microtubule associated complex|
|neuromuscular synaptic transmission|
|kinesin binding|
|anterograde axonal transport|
|vesicle transport along microtubule|
|lysosome localization|
|mitochondrion localization|
|vesicle cytoskeletal trafficking|
|cellular response to nerve growth factor stimulus|
|response to nerve growth factor|
|kinesin complex|
|axonal transport|
|axon cytoplasm|
|scaffold protein binding|
|axo-dendritic transport|
|microtubule motor activity|
|organelle transport along microtubule|
|kinase binding|
|response to antineoplastic agent|
|cytoplasmic vesicle membrane|
|cytosolic transport|
|transport along microtubule|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|vesicle localization|
|response to ketone|
|protein localization to cell periphery|
|ATPase activity|
|microtubule binding|
|cytoplasmic vesicle|
|microtubule-based movement|
|axon|
|microtubule|
|neuron projection|
|establishment of organelle localization|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|dendrite|
|trans-synaptic signaling|
|synaptic signaling|
|cellular response to growth factor stimulus|
|response to toxic substance|
|response to growth factor|
|organelle localization|
|microtubule-based process|
|response to organic cyclic compound|
|apoptotic process|
|response to drug|
|programmed cell death|
|cell death|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|mitochondrion|
|response to endogenous stimulus|
|ATP binding|
|intracellular transport|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of localization in cell|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.77|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.76|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.85|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.01|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14655
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF1B Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>