======= KIF3C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF3C
  * **<color #00a2e8>Official Name</color>**: kinesin family member 3C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3797|3797]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14782|O14782]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF3C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF3C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602845|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule-based anterograde translocator for membranous organelles. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intraciliary transport involved in cilium assembly|
|motor activity|
|ciliary tip|
|intraciliary transport|
|kinesin complex|
|protein transport along microtubule|
|microtubule motor activity|
|microtubule-based protein transport|
|organelle transport along microtubule|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|cilium|
|antigen processing and presentation|
|ATPase activity|
|microtubule binding|
|protein-containing complex localization|
|microtubule-based movement|
|microtubule|
|cilium assembly|
|establishment of organelle localization|
|cilium organization|
|Golgi vesicle transport|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|organelle localization|
|microtubule-based process|
|organelle assembly|
|intracellular protein transport|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.56|
|[[:human genes:d:disp2|DISP2]]|0.508|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.503|
|[[:human genes:r:rps12|RPS12]]|0.498|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.497|
|[[:human genes:p:psmc1|PSMC1]]|0.49|
|[[:human genes:v:vasn|VASN]]|0.49|
|[[:human genes:c:copg1|COPG1]]|0.49|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.49|
|[[:human genes:o:ogfr|OGFR]]|0.487|
|[[:human genes:n:nup133|NUP133]]|0.481|
|[[:human genes:p:pola1|POLA1]]|0.481|
|[[:human genes:s:sf3a1|SF3A1]]|0.481|
|[[:human genes:n:npipb5|NPIPB5]]|0.476|
|[[:human genes:m:myt1l|MYT1L]]|0.473|
|[[:human genes:t:tceb3c|TCEB3C]]|0.471|
|[[:human genes:c:c14orf93|C14orf93]]|0.471|
|[[:human genes:h:hivep3|HIVEP3]]|0.469|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.468|
|[[:human genes:c:chd4|CHD4]]|0.464|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.463|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.462|
|[[:human genes:i:igfn1|IGFN1]]|0.462|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.462|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.462|
|[[:human genes:s:snip1|SNIP1]]|0.461|
|[[:human genes:n:napa|NAPA]]|0.458|
|[[:human genes:s:slc4a1|SLC4A1]]|0.458|
|[[:human genes:r:rps2|RPS2]]|0.456|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.455|
|[[:human genes:c:cbwd3|CBWD3]]|0.452|
|[[:human genes:c:cbwd5|CBWD5]]|0.452|
|[[:human genes:z:znf106|ZNF106]]|0.45|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.449|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.449|
|[[:human genes:f:fam160a1|FAM160A1]]|0.448|
|[[:human genes:r:rps28|RPS28]]|0.447|
|[[:human genes:m:med29|MED29]]|0.447|
|[[:human genes:d:ddtl|DDTL]]|0.447|
|[[:human genes:p:psmd3|PSMD3]]|0.447|
|[[:human genes:p:psmc2|PSMC2]]|0.445|
|[[:human genes:t:tfip11|TFIP11]]|0.444|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.443|
|[[:human genes:p:pwp2|PWP2]]|0.443|
|[[:human genes:a:aamp|AAMP]]|0.442|
|[[:human genes:c:cope|COPE]]|0.441|
|[[:human genes:u:upf1|UPF1]]|0.441|
|[[:human genes:m:myb|MYB]]|0.44|
|[[:human genes:p:psmc6|PSMC6]]|0.438|
|[[:human genes:o:orc1|ORC1]]|0.438|
|[[:human genes:k:kctd17|KCTD17]]|0.437|
|[[:human genes:s:sec13|SEC13]]|0.436|
|[[:human genes:d:dnm2|DNM2]]|0.436|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.434|
|[[:human genes:r:rrp7a|RRP7A]]|0.433|
|[[:human genes:n:narfl|NARFL]]|0.433|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.432|
|[[:human genes:l:lipe|LIPE]]|0.431|
|[[:human genes:a:akt1s1|AKT1S1]]|0.43|
|[[:human genes:p:psmb4|PSMB4]]|0.429|
|[[:human genes:m:myo1h|MYO1H]]|0.429|
|[[:human genes:e:exosc6|EXOSC6]]|0.429|
|[[:human genes:m:mylk3|MYLK3]]|0.426|
|[[:human genes:r:ranbp2|RANBP2]]|0.425|
|[[:human genes:c:copa|COPA]]|0.425|
|[[:human genes:p:polr2d|POLR2D]]|0.424|
|[[:human genes:s:sprr2b|SPRR2B]]|0.424|
|[[:human genes:s:supt5h|SUPT5H]]|0.423|
|[[:human genes:r:rbbp5|RBBP5]]|0.423|
|[[:human genes:c:ccna2|CCNA2]]|0.422|
|[[:human genes:v:vps54|VPS54]]|0.422|
|[[:human genes:c:cwc22|CWC22]]|0.422|
|[[:human genes:p:psmd11|PSMD11]]|0.421|
|[[:human genes:p:psmd7|PSMD7]]|0.419|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.419|
|[[:human genes:r:rps19|RPS19]]|0.418|
|[[:human genes:g:golga8o|GOLGA8O]]|0.418|
|[[:human genes:p:prss8|PRSS8]]|0.418|
|[[:human genes:c:chaf1a|CHAF1A]]|0.417|
|[[:human genes:a:akirin2|AKIRIN2]]|0.416|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.416|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.415|
|[[:human genes:d:dtl|DTL]]|0.415|
|[[:human genes:g:gar1|GAR1]]|0.414|
|[[:human genes:i:iscu|ISCU]]|0.413|
|[[:human genes:r:rps5|RPS5]]|0.413|
|[[:human genes:t:tpx2|TPX2]]|0.413|
|[[:human genes:e:egr2|EGR2]]|0.412|
|[[:human genes:r:rbm39|RBM39]]|0.412|
|[[:human genes:n:nol10|NOL10]]|0.411|
|[[:human genes:e:exosc5|EXOSC5]]|0.411|
|[[:human genes:n:nsf|NSF]]|0.41|
|[[:human genes:f:fam25b|FAM25B]]|0.41|
|[[:human genes:n:nupl1|NUPL1]]|0.408|
|[[:human genes:a:atp1a3|ATP1A3]]|0.408|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.407|
|[[:human genes:r:rpl30|RPL30]]|0.407|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.407|
|[[:human genes:e:exosc4|EXOSC4]]|0.407|
|[[:human genes:s:sap30bp|SAP30BP]]|0.407|
|[[:human genes:a:ankle1|ANKLE1]]|0.406|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.406|
|[[:human genes:r:rpsa|RPSA]]|0.405|
|[[:human genes:c:cdh24|CDH24]]|0.405|
|[[:human genes:b:brd4|BRD4]]|0.405|
|[[:human genes:r:rnf4|RNF4]]|0.405|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.404|
|[[:human genes:m:med12|MED12]]|0.404|
|[[:human genes:s:sprr2a|SPRR2A]]|0.404|
|[[:human genes:a:acsf2|ACSF2]]|0.404|
|[[:human genes:s:slc5a5|SLC5A5]]|0.404|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.403|
|[[:human genes:s:sf3b3|SF3B3]]|0.402|
|[[:human genes:s:syt9|SYT9]]|0.402|
|[[:human genes:c:cbwd6|CBWD6]]|0.401|
|[[:human genes:p:pan3|PAN3]]|0.401|
|[[:human genes:r:rps20|RPS20]]|0.401|
|[[:human genes:s:s1pr4|S1PR4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2171
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF3C Expression in NALM6 Cells: 4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>