======= KIF5C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF5C
  * **<color #00a2e8>Official Name</color>**: kinesin family member 5C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3800|3800]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60282|O60282]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF5C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF5C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604593|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|distal axon|
|anterograde dendritic transport of neurotransmitter receptor complex|
|anterograde dendritic transport|
|protein localization to presynapse|
|dendritic transport|
|anterograde axonal protein transport|
|ciliary rootlet|
|axo-dendritic protein transport|
|ATP-dependent microtubule motor activity, plus-end-directed|
|motor neuron axon guidance|
|axonal growth cone|
|dendrite cytoplasm|
|neurotransmitter receptor transport|
|synaptic vesicle transport|
|synaptic vesicle localization|
|receptor localization to synapse|
|anterograde axonal transport|
|kinesin complex|
|axonal transport|
|axon cytoplasm|
|protein localization to synapse|
|axo-dendritic transport|
|protein transport along microtubule|
|microtubule-based protein transport|
|microtubule motor activity|
|mRNA transport|
|transport along microtubule|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|vesicle localization|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|ATPase activity|
|microtubule binding|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|axon guidance|
|neuron projection guidance|
|microtubule-based movement|
|microtubule|
|establishment of organelle localization|
|axonogenesis|
|neuronal cell body|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|organelle localization|
|neuron projection development|
|microtubule-based process|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|intracellular protein transport|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|ATP binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12829
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF5C Expression in NALM6 Cells: -0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>