======= KLF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLF4
  * **<color #00a2e8>Official Name</color>**: Kruppel like factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9314|9314]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43474|O43474]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602253|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of leukocyte adhesion to arterial endothelial cell|
|RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity|
|negative regulation of chemokine (C-X-C motif) ligand 2 production|
|negative regulation of muscle hyperplasia|
|regulation of leukocyte adhesion to arterial endothelial cell|
|cellular response to cycloheximide|
|positive regulation of hemoglobin biosynthetic process|
|post-embryonic hemopoiesis|
|regulation of muscle hyperplasia|
|mesodermal cell fate determination|
|regulation of hemoglobin biosynthetic process|
|response to cycloheximide|
|phosphatidylinositol 3-kinase regulator activity|
|negative regulation of interleukin-8 biosynthetic process|
|negative regulation of leukocyte adhesion to vascular endothelial cell|
|transcription cofactor binding|
|positive regulation of core promoter binding|
|cellular response to laminar fluid shear stress|
|post-embryonic camera-type eye development|
|regulation of core promoter binding|
|pri-miRNA transcription by RNA polymerase II|
|regulation of cell-cell adhesion involved in gastrulation|
|negative regulation of heterotypic cell-cell adhesion|
|response to fungicide|
|regulation of chemokine (C-X-C motif) ligand 2 production|
|negative regulation of muscle adaptation|
|negative regulation of phosphatidylinositol 3-kinase signaling|
|mesodermal cell fate commitment|
|response to laminar fluid shear stress|
|negative regulation of cell migration involved in sprouting angiogenesis|
|post-embryonic animal organ development|
|regulation of interleukin-8 biosynthetic process|
|cellular response to fluid shear stress|
|negative regulation of interleukin-8 production|
|negative regulation of chemokine production|
|regulation of leukocyte adhesion to vascular endothelial cell|
|negative regulation of sprouting angiogenesis|
|nuclear transcription factor complex|
|positive regulation of transcription regulatory region DNA binding|
|regulation of axon regeneration|
|regulation of heterotypic cell-cell adhesion|
|mesodermal cell differentiation|
|cell fate commitment involved in formation of primary germ layer|
|epidermis morphogenesis|
|regulation of neuron projection regeneration|
|nuclear euchromatin|
|negative regulation of cytokine biosynthetic process|
|proximal promoter sequence-specific DNA binding|
|negative regulation of blood vessel endothelial cell migration|
|response to fluid shear stress|
|positive regulation of telomerase activity|
|regulation of gastrulation|
|regulation of cell migration involved in sprouting angiogenesis|
|cell fate determination|
|positive regulation of sprouting angiogenesis|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|negative regulation of smooth muscle cell proliferation|
|negative regulation of protein kinase B signaling|
|negative regulation of endothelial cell migration|
|promoter-specific chromatin binding|
|positive regulation of reactive oxygen species biosynthetic process|
|regulation of telomerase activity|
|regulation of transcription regulatory region DNA binding|
|regulation of phosphatidylinositol 3-kinase activity|
|regulation of nitric oxide biosynthetic process|
|positive regulation of DNA binding|
|RNA polymerase II transcription factor binding|
|regulation of lipid kinase activity|
|somatic stem cell population maintenance|
|negative regulation of response to cytokine stimulus|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of epithelial cell migration|
|positive regulation of DNA biosynthetic process|
|mesoderm formation|
|regulation of interleukin-8 production|
|regulation of sprouting angiogenesis|
|mesoderm morphogenesis|
|cellular response to retinoic acid|
|cellular response to hydrogen peroxide|
|regulation of chemokine production|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|beta-catenin binding|
|regulation of phospholipid metabolic process|
|cellular response to alcohol|
|regulation of reactive oxygen species biosynthetic process|
|regulation of muscle adaptation|
|post-embryonic development|
|canonical Wnt signaling pathway|
|regulation of blood vessel endothelial cell migration|
|negative regulation of cysteine-type endopeptidase activity|
|cellular response to ketone|
|positive regulation of reactive oxygen species metabolic process|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of angiogenesis|
|regulation of cytokine biosynthetic process|
|negative regulation of blood vessel morphogenesis|
|fat cell differentiation|
|negative regulation of cell cycle G1/S phase transition|
|response to retinoic acid|
|formation of primary germ layer|
|histone deacetylase binding|
|regulation of DNA biosynthetic process|
|negative regulation of vasculature development|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of leukocyte cell-cell adhesion|
|mesoderm development|
|regulation of DNA binding|
|regulation of embryonic development|
|cellular response to reactive oxygen species|
|regulation of smooth muscle cell proliferation|
|stem cell population maintenance|
|negative regulation of inflammatory response|
|maintenance of cell number|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of endothelial cell migration|
|gastrulation|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of angiogenesis|
|regulation of cell cycle G1/S phase transition|
|regulation of response to wounding|
|negative regulation of MAPK cascade|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|positive regulation of binding|
|regulation of reactive oxygen species metabolic process|
|positive regulation of vasculature development|
|response to ketone|
|positive regulation of DNA metabolic process|
|response to reactive oxygen species|
|negative regulation of defense response|
|cellular response to acid chemical|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to toxic substance|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|transcription regulatory region DNA binding|
|regulation of epithelial cell migration|
|regulation of protein kinase B signaling|
|negative regulation of cell cycle phase transition|
|response to alcohol|
|regulation of muscle system process|
|nuclear chromatin|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|cell fate commitment|
|negative regulation of peptidase activity|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|negative regulation of mitotic cell cycle|
|negative regulation of cellular component movement|
|camera-type eye development|
|epidermal cell differentiation|
|regulation of vasculature development|
|negative regulation of locomotion|
|negative regulation of cell cycle process|
|cellular response to peptide|
|regulation of inflammatory response|
|response to acid chemical|
|regulation of neurotransmitter levels|
|negative regulation of proteolysis|
|regulation of DNA metabolic process|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|negative regulation of response to external stimulus|
|sensory system development|
|regulation of binding|
|response to oxidative stress|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|epidermis development|
|regulation of endopeptidase activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of cell cycle phase transition|
|negative regulation of hydrolase activity|
|response to peptide|
|transcription by RNA polymerase II|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|cellular response to lipid|
|response to growth factor|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|sensory organ development|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|regulation of system process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|regulation of cell projection organization|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of defense response|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|zinc ion binding|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|epithelium development|
|cell-cell signaling|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.78|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4505
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLF4 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>