======= KLF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLF5
  * **<color #00a2e8>Official Name</color>**: Kruppel like factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=688|688]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13887|Q13887]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602903|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|satellite cell activation involved in skeletal muscle regeneration|
|cell-cell signaling via exosome|
|positive regulation of transcription by transcription factor localization|
|skeletal muscle satellite cell activation|
|MRF binding|
|skeletal muscle satellite cell differentiation|
|regulation of microvillus assembly|
|myotube differentiation involved in skeletal muscle regeneration|
|intestinal epithelial cell development|
|regulation of microvillus organization|
|microvillus assembly|
|microvillus organization|
|intestinal epithelial cell differentiation|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|skeletal muscle tissue regeneration|
|regulation of pri-miRNA transcription by RNA polymerase II|
|columnar/cuboidal epithelial cell development|
|skeletal muscle cell differentiation|
|myotube differentiation|
|positive regulation of fat cell differentiation|
|tissue regeneration|
|columnar/cuboidal epithelial cell differentiation|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|regulation of fat cell differentiation|
|skeletal muscle tissue development|
|digestive tract development|
|skeletal muscle organ development|
|digestive system development|
|regeneration|
|epithelial cell development|
|regulation of plasma membrane bounded cell projection assembly|
|striated muscle cell differentiation|
|regulation of cell projection assembly|
|transcription factor complex|
|muscle cell differentiation|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|angiogenesis|
|cellular response to peptide|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|plasma membrane bounded cell projection assembly|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|cell projection assembly|
|response to peptide|
|muscle structure development|
|wound healing|
|transcription by RNA polymerase II|
|blood vessel development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|cellular response to organic cyclic compound|
|response to wounding|
|cellular response to organonitrogen compound|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|Golgi apparatus|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 52/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|0/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|4/26|
|pancreas|5/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17090
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLF5 Expression in NALM6 Cells: 1.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>