======= KLHL24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLHL24
  * **<color #00a2e8>Official Name</color>**: kelch like family member 24
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54800|54800]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6TFL4|Q6TFL4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLHL24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLHL24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:27889062}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
|Kelch 1|
|BACK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of kainate selective glutamate receptor activity|
|intermediate filament organization|
|desmosome|
|Cul3-RING ubiquitin ligase complex|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|regulation of sodium ion transmembrane transporter activity|
|regulation of potassium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|adherens junction|
|regulation of glutamate receptor signaling pathway|
|protein autoubiquitination|
|regulation of neurotransmitter receptor activity|
|regulation of potassium ion transmembrane transport|
|regulation of sodium ion transport|
|regulation of potassium ion transport|
|perikaryon|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|axon|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|supramolecular fiber organization|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|protein ubiquitination|
|regulation of ion transport|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|cytoskeleton organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.76|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.71|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9670
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLHL24 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>