======= KLHL40 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLHL40
  * **<color #00a2e8>Official Name</color>**: kelch like family member 40
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=131377|131377]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2TBA0|Q2TBA0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLHL40&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLHL40|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615340|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein containing a BACK domain, a BTB/POZ domain, and 5 Kelch repeats, however, its exact function is not known. The gene and the multi-domain protein structure are conserved across different taxa, including primates, rodents, chicken and zebrafish. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity). {ECO:0000250|UniProtKB:Q9D783, ECO:0000269|PubMed:23746549}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BACK|
|Kelch 1|
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|skeletal muscle fiber differentiation|
|A band|
|I band|
|skeletal muscle fiber development|
|myotube cell development|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|Cul3-RING ubiquitin ligase complex|
|negative regulation of ubiquitin-dependent protein catabolic process|
|skeletal muscle cell differentiation|
|myotube differentiation|
|negative regulation of proteasomal protein catabolic process|
|muscle fiber development|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of protein ubiquitination|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein modification by small protein conjugation or removal|
|negative regulation of cellular protein catabolic process|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of protein ubiquitination|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|negative regulation of protein catabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|striated muscle cell development|
|positive regulation of cellular protein catabolic process|
|muscle cell development|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of proteasomal protein catabolic process|
|regulation of protein ubiquitination|
|striated muscle cell differentiation|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|muscle cell differentiation|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|muscle structure development|
|negative regulation of protein modification process|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|positive regulation of protein modification process|
|positive regulation of cellular protein metabolic process|
|cell development|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14448
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLHL40 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>