======= KLRK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLRK1
  * **<color #00a2e8>Official Name</color>**: killer cell lectin like receptor K1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22914|22914]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26718|P26718]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLRK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLRK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611817|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19658097, ECO:0000269|PubMed:21898152, ECO:0000269|PubMed:23298206, ECO:0000269|PubMed:28559451}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of natural killer cell chemotaxis|
|negative regulation of lymphocyte chemotaxis|
|MHC class Ib receptor activity|
|regulation of natural killer cell chemotaxis|
|negative regulation of lymphocyte migration|
|negative regulation of leukocyte chemotaxis|
|MHC class I protein binding|
|regulation of lymphocyte chemotaxis|
|natural killer cell mediated cytotoxicity|
|natural killer cell mediated immunity|
|positive regulation of natural killer cell mediated cytotoxicity|
|positive regulation of natural killer cell mediated immunity|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|leukocyte mediated cytotoxicity|
|regulation of natural killer cell mediated cytotoxicity|
|negative regulation of leukocyte migration|
|regulation of natural killer cell mediated immunity|
|negative regulation of GTPase activity|
|positive regulation of reactive oxygen species biosynthetic process|
|T cell costimulation|
|lymphocyte costimulation|
|positive regulation of leukocyte mediated cytotoxicity|
|regulation of nitric oxide biosynthetic process|
|negative regulation of chemotaxis|
|natural killer cell activation|
|regulation of lymphocyte migration|
|positive regulation of interferon-gamma production|
|positive regulation of cell killing|
|regulation of leukocyte mediated cytotoxicity|
|regulation of reactive oxygen species biosynthetic process|
|cell killing|
|defense response to Gram-positive bacterium|
|positive regulation of reactive oxygen species metabolic process|
|regulation of interferon-gamma production|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|stimulatory C-type lectin receptor signaling pathway|
|regulation of leukocyte chemotaxis|
|innate immune response activating cell surface receptor signaling pathway|
|positive regulation of leukocyte mediated immunity|
|regulation of lymphocyte mediated immunity|
|carbohydrate binding|
|regulation of reactive oxygen species metabolic process|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|positive regulation of T cell activation|
|signaling receptor activity|
|regulation of leukocyte mediated immunity|
|regulation of chemotaxis|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|innate immune response-activating signal transduction|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|negative regulation of cell migration|
|lymphocyte mediated immunity|
|negative regulation of cell motility|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of cellular component movement|
|response to lipopolysaccharide|
|regulation of T cell activation|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|defense response to bacterium|
|positive regulation of innate immune response|
|regulation of neurotransmitter levels|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|activation of immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|protein homodimerization activity|
|regulation of cell motility|
|leukocyte activation|
|defense response to other organism|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to oxygen-containing compound|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|immune response|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.73|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.8|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.81|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.87|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.89|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.95|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18490
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLRK1 Expression in NALM6 Cells: 4.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>