======= KPNA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KPNA2
  * **<color #00a2e8>Official Name</color>**: karyopherin subunit alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3838|3838]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52292|P52292]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KPNA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KPNA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600685|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBB|
|Arm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of postsynaptic specialization membrane|
|entry of viral genome into host nucleus through nuclear pore complex via importin|
|viral penetration into host nucleus|
|multi-organism nuclear import|
|multi-organism intracellular transport|
|multi-organism cellular localization|
|postsynapse to nucleus signaling pathway|
|NLS-bearing protein import into nucleus|
|modulation by virus of host cellular process|
|nuclear import signal receptor activity|
|nuclear localization sequence binding|
|modulation by symbiont of host cellular process|
|modulation by virus of host morphology or physiology|
|postsynaptic signal transduction|
|modification by symbiont of host morphology or physiology|
|intracellular transport of virus|
|host cell|
|transport of virus|
|positive regulation of viral life cycle|
|multi-organism localization|
|multi-organism transport|
|protein import into nucleus|
|regulation of DNA recombination|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|histone deacetylase binding|
|import into nucleus|
|protein import|
|regulation of viral life cycle|
|modification of morphology or physiology of other organism|
|interaction with host|
|protein localization to nucleus|
|viral life cycle|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|nucleocytoplasmic transport|
|nuclear transport|
|glutamatergic synapse|
|regulation of DNA metabolic process|
|establishment of protein localization to organelle|
|synaptic signaling|
|positive regulation of multi-organism process|
|viral process|
|protein localization to organelle|
|DNA metabolic process|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|intracellular protein transport|
|cell-cell signaling|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.23|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.22|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.1|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.92|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.78|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.71|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.81|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.84|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.84|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.87|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.98|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.03|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.25|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atxn7l3|ATXN7L3]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1201
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KPNA2 Expression in NALM6 Cells: 8.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>