======= KPNB1 =======
== Gene Information ==
* **Official Symbol**: KPNB1
* **Official Name**: karyopherin subunit beta 1
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3837|3837]]
* **UniProt**: [[https://www.uniprot.org/uniprot/Q14974|Q14974]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=KPNB1&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KPNB1|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/602738|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: N/A
* **UniProt Summary**: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. {ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:9687515}.
|IBN N|
|HEAT|
|Ran protein signal transduction|
|mitotic chromosome movement towards spindle pole|
|ribosomal protein import into nucleus|
|importin-alpha family protein binding|
|chromosome movement towards spindle pole|
|astral microtubule organization|
|endoplasmic reticulum tubular network|
|apoptotic DNA fragmentation|
|modulation by virus of host cellular process|
|nuclear import signal receptor activity|
|DNA catabolic process, endonucleolytic|
|nuclear localization sequence binding|
|apoptotic nuclear changes|
|modulation by symbiont of host cellular process|
|cellular component disassembly involved in execution phase of apoptosis|
|DNA catabolic process|
|modulation by virus of host morphology or physiology|
|establishment of mitotic spindle localization|
|Ran GTPase binding|
|mitotic spindle assembly|
|modification by symbiont of host morphology or physiology|
|Hsp90 protein binding|
|regulation of sterol biosynthetic process|
|establishment of spindle localization|
|regulation of cholesterol biosynthetic process|
|mitotic metaphase plate congression|
|spindle localization|
|execution phase of apoptosis|
|cytoplasmic microtubule organization|
|intracellular transport of virus|
|metaphase plate congression|
|host cell|
|regulation of cholesterol metabolic process|
|transport of virus|
|specific granule lumen|
|cytoplasmic stress granule|
|multi-organism transport|
|multi-organism localization|
|nuclear pore|
|establishment of chromosome localization|
|regulation of alcohol biosynthetic process|
|chromosome localization|
|mitotic spindle organization|
|regulation of steroid biosynthetic process|
|protein import into nucleus|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of steroid metabolic process|
|import into nucleus|
|ficolin-1-rich granule lumen|
|sister chromatid segregation|
|protein import|
|mitotic nuclear division|
|spindle organization|
|modification of morphology or physiology of other organism|
|interaction with host|
|protein localization to nucleus|
|nuclear envelope|
|regulation of lipid biosynthetic process|
|viral life cycle|
|nuclear chromosome segregation|
|nuclear membrane|
|protein domain specific binding|
|Ras protein signal transduction|
|nucleocytoplasmic transport|
|nuclear transport|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|nucleic acid phosphodiester bond hydrolysis|
|organelle fission|
|small GTPase mediated signal transduction|
|enzyme binding|
|establishment of organelle localization|
|nucleobase-containing compound catabolic process|
|regulation of lipid metabolic process|
|cellular component disassembly|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|organic cyclic compound catabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organelle localization|
|myeloid leukocyte activation|
|mitotic cell cycle process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|microtubule-based process|
|mitotic cell cycle|
|viral process|
|regulated exocytosis|
|protein localization to organelle|
|DNA metabolic process|
|organelle assembly|
|leukocyte mediated immunity|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|zinc ion binding|
|cellular macromolecule catabolic process|
|apoptotic process|
|leukocyte activation|
|intracellular protein transport|
|cell cycle process|
|secretion by cell|
|export from cell|
|macromolecule catabolic process|
|programmed cell death|
|chromosome organization|
|cell activation|
|immune effector process|
|cell death|
|cytoskeleton organization|
|secretion|
|cell cycle|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.69|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.51|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.49|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.31|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.3|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.29|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.18|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.14|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.14|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.08|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.87|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.85|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.82|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.81|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.77|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.71|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.71|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.72|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.73|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.74|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.78|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.79|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.8|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.88|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.88|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.9|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.9|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.92|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.93|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.98|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.01|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.05|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.08|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|2.09|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.1|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|2.13|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|2.16|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.16|
|[[:results:exp100|NFN1 1μM R03 exp100]]|2.18|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.22|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.34|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.35|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.36|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.45|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.52|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.62|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.64|
^Gene^Correlation^
|[[:human genes:p:pan3|PAN3]]|0.517|
|[[:human genes:v:vasn|VASN]]|0.515|
|[[:human genes:p:psmd11|PSMD11]]|0.505|
|[[:human genes:p:psma6|PSMA6]]|0.505|
|[[:human genes:a:atp13a1|ATP13A1]]|0.502|
|[[:human genes:p:psmc6|PSMC6]]|0.494|
|[[:human genes:d:dtl|DTL]]|0.492|
|[[:human genes:t:tceb3c|TCEB3C]]|0.491|
|[[:human genes:c:chd4|CHD4]]|0.49|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.482|
|[[:human genes:a:aaas|AAAS]]|0.481|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.48|
|[[:human genes:p:psmd1|PSMD1]]|0.469|
|[[:human genes:s:supt6h|SUPT6H]]|0.467|
|[[:human genes:p:psmd3|PSMD3]]|0.467|
|[[:human genes:s:smg7|SMG7]]|0.466|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.465|
|[[:human genes:a:aamp|AAMP]]|0.462|
|[[:human genes:p:psmc2|PSMC2]]|0.462|
|[[:human genes:r:rpl35|RPL35]]|0.46|
|[[:human genes:a:ahctf1|AHCTF1]]|0.458|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.457|
|[[:human genes:l:lrr1|LRR1]]|0.456|
|[[:human genes:z:zfand5|ZFAND5]]|0.455|
|[[:human genes:e:exosc9|EXOSC9]]|0.455|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.454|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.453|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.453|
|[[:human genes:s:ssh2|SSH2]]|0.452|
|[[:human genes:r:rrp7a|RRP7A]]|0.45|
|[[:human genes:s:smg1|SMG1]]|0.45|
|[[:human genes:n:nupl1|NUPL1]]|0.449|
|[[:human genes:z:znf106|ZNF106]]|0.444|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.442|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.442|
|[[:human genes:c:clasp1|CLASP1]]|0.442|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.441|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.441|
|[[:human genes:m:mt1e|MT1E]]|0.44|
|[[:human genes:t:ticrr|TICRR]]|0.44|
|[[:human genes:a:ankle2|ANKLE2]]|0.438|
|[[:human genes:k:kctd17|KCTD17]]|0.436|
|[[:human genes:p:polr1a|POLR1A]]|0.434|
|[[:human genes:i:igfn1|IGFN1]]|0.433|
|[[:human genes:c:cbwd3|CBWD3]]|0.432|
|[[:human genes:r:rps2|RPS2]]|0.431|
|[[:human genes:u:upf1|UPF1]]|0.431|
|[[:human genes:p:psmb4|PSMB4]]|0.431|
|[[:human genes:o:orc1|ORC1]]|0.428|
|[[:human genes:p:pan2|PAN2]]|0.428|
|[[:human genes:p:psmc1|PSMC1]]|0.426|
|[[:human genes:o:ogfr|OGFR]]|0.426|
|[[:human genes:d:ddtl|DDTL]]|0.425|
|[[:human genes:n:nup160|NUP160]]|0.423|
|[[:human genes:r:rad21|RAD21]]|0.423|
|[[:human genes:c:cdca3|CDCA3]]|0.423|
|[[:human genes:p:psmd14|PSMD14]]|0.422|
|[[:human genes:a:apc2|APC2]]|0.421|
|[[:human genes:l:lad1|LAD1]]|0.42|
|[[:human genes:r:rps7|RPS7]]|0.418|
|[[:human genes:x:xylt2|XYLT2]]|0.417|
|[[:human genes:a:akirin2|AKIRIN2]]|0.415|
|[[:human genes:p:psmc3|PSMC3]]|0.414|
|[[:human genes:w:wdr43|WDR43]]|0.413|
|[[:human genes:n:nup43|NUP43]]|0.412|
|[[:human genes:o:orc6|ORC6]]|0.411|
|[[:human genes:c:cbwd5|CBWD5]]|0.411|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.411|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.411|
|[[:human genes:c:copb1|COPB1]]|0.409|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.408|
|[[:human genes:p:plk1|PLK1]]|0.408|
|[[:human genes:n:ndc1|NDC1]]|0.406|
|[[:human genes:a:atxn1|ATXN1]]|0.406|
|[[:human genes:n:nup54|NUP54]]|0.405|
|[[:human genes:c:cbwd6|CBWD6]]|0.405|
|[[:human genes:m:myo1h|MYO1H]]|0.405|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.404|
|[[:human genes:p:pwp2|PWP2]]|0.404|
|[[:human genes:b:brd8|BRD8]]|0.403|
|[[:human genes:w:wdr75|WDR75]]|0.402|
|[[:human genes:f:fam86b2|FAM86B2]]|0.402|
|[[:human genes:r:rrn3|RRN3]]|0.402|
|[[:human genes:c:ccna2|CCNA2]]|0.402|
|[[:human genes:s:snrpa1|SNRPA1]]|0.401|
|[[:human genes:p:psmb2|PSMB2]]|0.401|
|[[:human genes:p:prpf4|PRPF4]]|0.4|
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 14
* **Expression level (log2 read counts)**: 9.46
{{:chemogenomics:nalm6 dist.png?nolink |}}