======= KRAS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KRAS
  * **<color #00a2e8>Official Name</color>**: KRAS proto-oncogene, GTPase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3845|3845]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01116|P01116]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KRAS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KRAS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). {ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24623306, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|GTP EFTU|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endocrine signaling|
|forebrain astrocyte differentiation|
|forebrain astrocyte development|
|GMP binding|
|positive regulation of Rac protein signal transduction|
|response to isolation stress|
|LRR domain binding|
|positive regulation of cellular senescence|
|regulation of Rac protein signal transduction|
|positive regulation of cell aging|
|positive regulation of nitric-oxide synthase activity|
|epithelial tube branching involved in lung morphogenesis|
|positive regulation of monooxygenase activity|
|regulation of long-term neuronal synaptic plasticity|
|homeostasis of number of cells within a tissue|
|response to mineralocorticoid|
|regulation of synaptic transmission, GABAergic|
|astrocyte development|
|regulation of cellular senescence|
|lung morphogenesis|
|regulation of nitric-oxide synthase activity|
|endocrine process|
|visual learning|
|regulation of cell aging|
|positive regulation of oxidoreductase activity|
|astrocyte differentiation|
|visual behavior|
|regulation of neuronal synaptic plasticity|
|regulation of monooxygenase activity|
|extrinsic component of cytoplasmic side of plasma membrane|
|positive regulation of Ras protein signal transduction|
|positive regulation of small GTPase mediated signal transduction|
|GDP binding|
|associative learning|
|regulation of oxidoreductase activity|
|glial cell development|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|liver development|
|hepaticobiliary system development|
|branching morphogenesis of an epithelial tube|
|response to glucocorticoid|
|negative regulation of neuron apoptotic process|
|learning|
|positive regulation of NF-kappaB transcription factor activity|
|morphogenesis of a branching epithelium|
|response to corticosteroid|
|morphogenesis of a branching structure|
|lung development|
|glial cell differentiation|
|respiratory tube development|
|female pregnancy|
|regulation of synaptic plasticity|
|tissue homeostasis|
|respiratory system development|
|homeostasis of number of cells|
|striated muscle cell differentiation|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|multi-multicellular organism process|
|gliogenesis|
|membrane raft|
|innate immune response-activating signal transduction|
|regulation of Ras protein signal transduction|
|muscle cell differentiation|
|Ras protein signal transduction|
|activation of innate immune response|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|protein-containing complex binding|
|regulation of protein stability|
|cognition|
|epithelial tube morphogenesis|
|response to light stimulus|
|regulation of neuron death|
|small GTPase mediated signal transduction|
|multicellular organismal homeostasis|
|response to steroid hormone|
|GTPase activity|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|forebrain development|
|GTP binding|
|signal transduction by protein phosphorylation|
|gland development|
|focal adhesion|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|muscle structure development|
|immune response-regulating cell surface receptor signaling pathway|
|actin cytoskeleton organization|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|tissue morphogenesis|
|actin filament-based process|
|behavior|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|tube morphogenesis|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|brain development|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|head development|
|regulation of protein kinase activity|
|tube development|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|negative regulation of developmental process|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|negative regulation of cell death|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|phosphorylation|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.7|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.7|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.79|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.79|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.89|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.22|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.49|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 106/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|3/28|
|bone|0/26|
|breast|5/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|12/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|0/21|
|liver|0/20|
|lung|19/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|20/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|2/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7620
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KRAS Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>