======= KREMEN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KREMEN1
  * **<color #00a2e8>Official Name</color>**: kringle containing transmembrane protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83999|83999]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MU8|Q96MU8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KREMEN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KREMEN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609898|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WSC|
|CUB|
|Kringle|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of axon regeneration|
|negative regulation of neuron projection regeneration|
|regulation of axon regeneration|
|regulation of neuron projection regeneration|
|negative regulation of ossification|
|negative regulation of response to wounding|
|negative regulation of neuron projection development|
|regulation of response to wounding|
|negative regulation of canonical Wnt signaling pathway|
|limb development|
|appendage development|
|negative regulation of cell projection organization|
|regulation of ossification|
|negative regulation of Wnt signaling pathway|
|negative regulation of neuron differentiation|
|regulation of canonical Wnt signaling pathway|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|negative regulation of response to external stimulus|
|neuronal cell body|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of neuron projection development|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of neurogenesis|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|programmed cell death|
|cell death|
|regulation of response to external stimulus|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.75|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.7|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.73|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.74|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.74|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.75|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.78|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.79|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.84|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.88|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.08|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.18|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.24|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.6|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tra2b|TRA2B]]|0.441|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2307
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KREMEN1 Expression in NALM6 Cells: 3.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>