======= KRT8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KRT8
  * **<color #00a2e8>Official Name</color>**: keratin 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3856|3856]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05787|P05787]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KRT8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KRT8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/148060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to hydrostatic pressure|
|hepatocyte apoptotic process|
|response to water|
|dystrophin-associated glycoprotein complex|
|apicolateral plasma membrane|
|costamere|
|cell differentiation involved in embryonic placenta development|
|epithelial cell apoptotic process|
|sarcomere organization|
|intermediate filament cytoskeleton|
|scaffold protein binding|
|myofibril assembly|
|embryonic placenta development|
|extrinsic apoptotic signaling pathway|
|keratin filament|
|sarcolemma|
|cellular component assembly involved in morphogenesis|
|nuclear matrix|
|cornification|
|actomyosin structure organization|
|intermediate filament|
|tumor necrosis factor-mediated signaling pathway|
|Z disc|
|striated muscle cell development|
|muscle cell development|
|placenta development|
|cell-cell junction|
|striated muscle cell differentiation|
|keratinization|
|cellular response to tumor necrosis factor|
|muscle cell differentiation|
|response to tumor necrosis factor|
|protein-containing complex binding|
|keratinocyte differentiation|
|apoptotic signaling pathway|
|epidermal cell differentiation|
|response to acid chemical|
|in utero embryonic development|
|skin development|
|epidermis development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|response to inorganic substance|
|actin filament-based process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|viral process|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|embryo development|
|cellular response to cytokine stimulus|
|programmed cell death|
|cell death|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|response to abiotic stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14081
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KRT8 Expression in NALM6 Cells: 3.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>