======= LACRT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LACRT
  * **<color #00a2e8>Official Name</color>**: lacritin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90070|90070]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZZ8|Q9GZZ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LACRT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LACRT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Modulates secretion by lacrimal acinar cells.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tear secretion|
|laminin-1 binding|
|positive regulation of epithelial cell proliferation involved in wound healing|
|calcineurin-NFAT signaling cascade|
|negative regulation of lipopolysaccharide-mediated signaling pathway|
|calcineurin-mediated signaling|
|positive regulation of calcineurin-mediated signaling|
|positive regulation of calcineurin-NFAT signaling cascade|
|secretion by tissue|
|inositol phosphate-mediated signaling|
|regulation of lipopolysaccharide-mediated signaling pathway|
|epithelial structure maintenance|
|fibronectin binding|
|protein localization to Golgi apparatus|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|positive regulation of release of sequestered calcium ion into cytosol|
|positive regulation of calcium-mediated signaling|
|positive regulation of calcium ion transport into cytosol|
|collagen binding|
|positive regulation of macroautophagy|
|positive regulation of calcium ion transmembrane transport|
|body fluid secretion|
|regulation of release of sequestered calcium ion into cytosol|
|secretory granule|
|negative regulation of response to biotic stimulus|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|protein N-terminus binding|
|positive regulation of autophagy|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|positive regulation of cation transmembrane transport|
|protein acetylation|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|growth factor activity|
|regulation of macroautophagy|
|protein acylation|
|positive regulation of epithelial cell proliferation|
|tissue homeostasis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of transmembrane transport|
|negative regulation of multi-organism process|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|defense response to bacterium|
|regulation of autophagy|
|regulation of epithelial cell proliferation|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|anatomical structure homeostasis|
|negative regulation of response to external stimulus|
|positive regulation of cellular catabolic process|
|regulation of metal ion transport|
|positive regulation of catabolic process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|regulation of response to biotic stimulus|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|response to wounding|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|response to bacterium|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|protein localization to organelle|
|cellular chemical homeostasis|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of secretion|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|defense response to other organism|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|chemical homeostasis|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12044
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LACRT Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>