======= LAMA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMA3
  * **<color #00a2e8>Official Name</color>**: laminin subunit alpha 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3909|3909]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16787|Q16787]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600805|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin G 1|
|Laminin II|
|Laminin N|
|Laminin I|
|Laminin EGF|
|Laminin B|
|Laminin G 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|laminin-5 complex|
|hemidesmosome assembly|
|endodermal cell differentiation|
|cell-substrate junction assembly|
|morphogenesis of a polarized epithelium|
|endoderm formation|
|endoderm development|
|basement membrane|
|integrin-mediated signaling pathway|
|formation of primary germ layer|
|regulation of embryonic development|
|integrin binding|
|extracellular matrix structural constituent|
|gastrulation|
|cell junction assembly|
|structural molecule activity|
|cell junction organization|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|epidermis development|
|morphogenesis of an epithelium|
|cell-cell adhesion|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of cell adhesion|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|endoplasmic reticulum|
|cell motility|
|localization of cell|
|epithelium development|
|locomotion|
|movement of cell or subcellular component|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8740
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.66 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMA3 Expression in NALM6 Cells: 0.66'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>