======= LAMB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMB2
  * **<color #00a2e8>Official Name</color>**: laminin subunit beta 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3913|3913]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55268|P55268]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/150325|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin EGF|
|Laminin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sprouting of injured axon|
|metanephric glomerular basement membrane development|
|axon extension involved in regeneration|
|laminin-3 complex|
|metanephric glomerular epithelial cell differentiation|
|metanephric glomerular visceral epithelial cell development|
|metanephric glomerular visceral epithelial cell differentiation|
|metanephric glomerular epithelium development|
|metanephric glomerular epithelial cell development|
|laminin-11 complex|
|laminin complex|
|basement membrane assembly|
|glomerular visceral epithelial cell development|
|glomerular basement membrane development|
|glomerular epithelial cell development|
|metanephric glomerulus development|
|synaptic cleft|
|renal filtration cell differentiation|
|glomerular visceral epithelial cell differentiation|
|cell differentiation involved in metanephros development|
|glomerular epithelial cell differentiation|
|metanephric nephron epithelium development|
|glomerular epithelium development|
|metanephric epithelium development|
|basement membrane organization|
|axon regeneration|
|Schwann cell development|
|neuron projection regeneration|
|epithelial cell differentiation involved in kidney development|
|metanephric nephron development|
|axon extension|
|Schwann cell differentiation|
|astrocyte development|
|cell differentiation involved in kidney development|
|neuromuscular junction development|
|response to axon injury|
|glomerulus development|
|substrate adhesion-dependent cell spreading|
|astrocyte differentiation|
|neuron projection extension|
|peripheral nervous system development|
|neuromuscular junction|
|metanephros development|
|developmental cell growth|
|basement membrane|
|cell growth|
|nephron epithelium development|
|glial cell development|
|developmental growth involved in morphogenesis|
|nephron development|
|kidney epithelium development|
|integrin binding|
|extracellular matrix structural constituent|
|retina development in camera-type eye|
|regeneration|
|glial cell differentiation|
|cell-substrate adhesion|
|epithelial cell development|
|structural molecule activity|
|gliogenesis|
|visual perception|
|sensory perception of light stimulus|
|axon guidance|
|neuron projection guidance|
|kidney development|
|synapse organization|
|renal system development|
|endoplasmic reticulum lumen|
|camera-type eye development|
|urogenital system development|
|extracellular matrix organization|
|eye development|
|visual system development|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|sensory system development|
|axonogenesis|
|extracellular structure organization|
|developmental growth|
|growth|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|response to wounding|
|neuron projection development|
|epithelial cell differentiation|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|sensory perception|
|central nervous system development|
|neuron differentiation|
|localization of cell|
|cell motility|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|nervous system process|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|cellular response to stress|
|tissue development|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7895
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMB2 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>