======= LAMTOR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMTOR1
  * **<color #00a2e8>Official Name</color>**: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55004|55004]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6IAA8|Q6IAA8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMTOR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMTOR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613510|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. {ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of sterol import|
|regulation of cholesterol import|
|Ragulator complex|
|regulation of cholesterol esterification|
|regulation of cholesterol efflux|
|regulation of receptor recycling|
|GTPase binding|
|positive regulation of TOR signaling|
|lysosome localization|
|regulation of cholesterol transport|
|regulation of sterol transport|
|molecular adaptor activity|
|azurophil granule membrane|
|lysosome organization|
|lytic vacuole organization|
|ficolin-1-rich granule membrane|
|cellular response to amino acid stimulus|
|endosome organization|
|cholesterol homeostasis|
|sterol homeostasis|
|specific granule membrane|
|regulation of TOR signaling|
|guanyl-nucleotide exchange factor activity|
|regulation of lipid transport|
|regulation of steroid metabolic process|
|response to amino acid|
|late endosome membrane|
|vacuole organization|
|lipid homeostasis|
|regulation of lipid localization|
|cell cycle arrest|
|regulation of macroautophagy|
|cellular response to acid chemical|
|membrane raft|
|endosomal transport|
|lysosome|
|vesicle organization|
|lysosomal membrane|
|regulation of autophagy|
|response to acid chemical|
|regulation of lipid metabolic process|
|regulation of cell growth|
|endomembrane system organization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of MAPK cascade|
|negative regulation of cell cycle|
|organelle localization|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|regulation of growth|
|regulated exocytosis|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cellular catabolic process|
|leukocyte activation|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|chemical homeostasis|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|cell cycle|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|intracellular transport|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.76|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.7|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.7|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.62|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lamtor2|LAMTOR2]]|0.602|
|[[:human genes:r:rraga|RRAGA]]|0.564|
|[[:human genes:f:flcn|FLCN]]|0.558|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.556|
|[[:human genes:f:fnip1|FNIP1]]|0.494|
|[[:human genes:m:mios|MIOS]]|0.466|
|[[:human genes:w:wdr24|WDR24]]|0.46|
|[[:human genes:w:wdr59|WDR59]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2151
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMTOR1 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>