======= LAMTOR4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMTOR4
  * **<color #00a2e8>Official Name</color>**: late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=389541|389541]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q0VGL1|Q0VGL1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMTOR4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMTOR4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618834|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. {ECO:0000269|PubMed:22980980}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ragulator complex|
|protein localization to lysosome|
|positive regulation of TOR signaling|
|molecular adaptor activity|
|protein localization to vacuole|
|cellular response to amino acid stimulus|
|regulation of TOR signaling|
|guanyl-nucleotide exchange factor activity|
|response to amino acid|
|cell cycle arrest|
|regulation of macroautophagy|
|regulation of cell size|
|cellular response to acid chemical|
|lysosome|
|lysosomal membrane|
|regulation of autophagy|
|response to acid chemical|
|regulation of cellular component size|
|regulation of anatomical structure size|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|protein localization to organelle|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|cell cycle|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-3.27|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-3.18|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.96|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.85|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.59|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.58|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.53|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.53|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.53|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.49|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.44|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.43|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.42|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.38|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.32|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-2.26|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.16|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.12|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.11|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.11|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.11|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.09|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.08|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.02|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.99|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.99|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.98|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.91|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.9|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.89|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.88|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.87|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.85|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.81|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.8|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.78|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.75|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.74|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.73|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.72|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.7|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.7|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.72|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.72|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.75|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.79|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.79|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.85|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.93|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.97|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.98|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.09|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.1|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.12|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.21|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.22|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.25|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.48|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.49|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.57|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.67|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.69|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.91|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.94|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr24|WDR24]]|0.724|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.698|
|[[:human genes:f:flcn|FLCN]]|0.682|
|[[:human genes:f:fnip1|FNIP1]]|0.665|
|[[:human genes:r:rraga|RRAGA]]|0.645|
|[[:human genes:r:rptor|RPTOR]]|0.626|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.605|
|[[:human genes:d:dohh|DOHH]]|0.6|
|[[:human genes:v:vps41|VPS41]]|0.568|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.563|
|[[:human genes:l:lamtor1|LAMTOR1]]|0.556|
|[[:human genes:w:wdr59|WDR59]]|0.554|
|[[:human genes:m:mios|MIOS]]|0.553|
|[[:human genes:f:fbxo11|FBXO11]]|0.499|
|[[:human genes:m:mlst8|MLST8]]|0.496|
|[[:human genes:m:mtor|MTOR]]|0.486|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.484|
|[[:human genes:c:cbfb|CBFB]]|0.477|
|[[:human genes:m:mllt1|MLLT1]]|0.474|
|[[:human genes:c:ccdc101|CCDC101]]|0.467|
|[[:human genes:t:thoc6|THOC6]]|0.466|
|[[:human genes:m:mapk14|MAPK14]]|0.462|
|[[:human genes:t:tbp|TBP]]|0.46|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.46|
|[[:human genes:g:gnb1l|GNB1L]]|0.457|
|[[:human genes:t:thg1l|THG1L]]|0.457|
|[[:human genes:r:rfwd2|RFWD2]]|0.455|
|[[:human genes:u:ube2g2|UBE2G2]]|0.455|
|[[:human genes:m:med23|MED23]]|0.452|
|[[:human genes:z:znf592|ZNF592]]|0.445|
|[[:human genes:b:bak1|BAK1]]|0.441|
|[[:human genes:t:tufm|TUFM]]|0.441|
|[[:human genes:v:vhl|VHL]]|0.439|
|[[:human genes:t:triap1|TRIAP1]]|0.438|
|[[:human genes:t:trnt1|TRNT1]]|0.437|
|[[:human genes:s:ssbp2|SSBP2]]|0.436|
|[[:human genes:v:vdac2|VDAC2]]|0.435|
|[[:human genes:p:ppa2|PPA2]]|0.435|
|[[:human genes:g:gfpt1|GFPT1]]|0.435|
|[[:human genes:i:id3|ID3]]|0.434|
|[[:human genes:r:romo1|ROMO1]]|0.431|
|[[:human genes:p:pmm2|PMM2]]|0.426|
|[[:human genes:s:srp14|SRP14]]|0.426|
|[[:human genes:m:meaf6|MEAF6]]|0.425|
|[[:human genes:a:actb|ACTB]]|0.425|
|[[:human genes:e:eny2|ENY2]]|0.424|
|[[:human genes:e:exoc4|EXOC4]]|0.424|
|[[:human genes:g:gmppb|GMPPB]]|0.424|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.423|
|[[:human genes:e:eif4e|EIF4E]]|0.422|
|[[:human genes:r:rnmt|RNMT]]|0.422|
|[[:human genes:o:opa1|OPA1]]|0.421|
|[[:human genes:c:cycs|CYCS]]|0.419|
|[[:human genes:d:dcaf5|DCAF5]]|0.416|
|[[:human genes:c:c21orf59|C21orf59]]|0.415|
|[[:human genes:c:casp9|CASP9]]|0.415|
|[[:human genes:l:lsm10|LSM10]]|0.415|
|[[:human genes:a:alg1|ALG1]]|0.414|
|[[:human genes:p:pim1|PIM1]]|0.413|
|[[:human genes:s:slc4a7|SLC4A7]]|0.412|
|[[:human genes:a:alg5|ALG5]]|0.412|
|[[:human genes:r:rpe|RPE]]|0.411|
|[[:human genes:a:atf7ip|ATF7IP]]|0.411|
|[[:human genes:r:rtcb|RTCB]]|0.41|
|[[:human genes:s:serf2|SERF2]]|0.41|
|[[:human genes:c:camk2g|CAMK2G]]|0.409|
|[[:human genes:a:adsl|ADSL]]|0.408|
|[[:human genes:h:haus8|HAUS8]]|0.407|
|[[:human genes:t:trmt10a|TRMT10A]]|0.407|
|[[:human genes:n:nsd1|NSD1]]|0.406|
|[[:human genes:e:eif3f|EIF3F]]|0.406|
|[[:human genes:t:tmem41b|TMEM41B]]|0.406|
|[[:human genes:d:dpagt1|DPAGT1]]|0.405|
|[[:human genes:c:casp3|CASP3]]|0.405|
|[[:human genes:p:pdpk1|PDPK1]]|0.403|
|[[:human genes:t:taz|TAZ]]|0.402|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.402|
|[[:human genes:u:uhrf1|UHRF1]]|0.401|
|[[:human genes:e:eed|EED]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 60/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|1/28|
|bone|1/26|
|breast|6/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|0/20|
|lung|6/75|
|lymphocyte|3/16|
|ovary|4/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11265
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMTOR4 Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>