======= LBR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LBR
  * **<color #00a2e8>Official Name</color>**: lamin B receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3930|3930]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14739|Q14739]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LBR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LBR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600024|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Anchors the lamina and the heterochromatin to the inner nuclear membrane. {ECO:0000269|PubMed:10828963}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LBR tudor|
|DUF1295|
|ERG4 ERG24|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|delta14-sterol reductase activity|
|neutrophil differentiation|
|chromo shadow domain binding|
|NADPH binding|
|lamin binding|
|integral component of nuclear inner membrane|
|granulocyte differentiation|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|nuclear inner membrane|
|sterol biosynthetic process|
|myeloid leukocyte differentiation|
|alcohol biosynthetic process|
|cholesterol metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|nuclear envelope|
|organic hydroxy compound biosynthetic process|
|myeloid cell differentiation|
|nuclear membrane|
|steroid metabolic process|
|alcohol metabolic process|
|leukocyte differentiation|
|organic hydroxy compound metabolic process|
|hemopoiesis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|hematopoietic or lymphoid organ development|
|immune system development|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|DNA binding|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9468
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LBR Expression in NALM6 Cells: 8.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>