======= LBX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LBX1
  * **<color #00a2e8>Official Name</color>**: ladybird homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10660|10660]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52954|P52954]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LBX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LBX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604255|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spinal cord association neuron specification|
|regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification|
|neuron fate determination|
|spinal cord association neuron differentiation|
|regulation of transcription involved in cell fate commitment|
|dorsal spinal cord development|
|neuron fate specification|
|spinal cord motor neuron differentiation|
|cell fate determination|
|ventral spinal cord development|
|cell differentiation in spinal cord|
|heart looping|
|neuron fate commitment|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube development|
|cell fate specification|
|spinal cord development|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|central nervous system neuron differentiation|
|transcription factor complex|
|negative regulation of neuron differentiation|
|cell fate commitment|
|heart morphogenesis|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|muscle organ development|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|sequence-specific DNA binding|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|muscle structure development|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|tube morphogenesis|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|tube development|
|circulatory system development|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|epithelium development|
|negative regulation of multicellular organismal process|
|generation of neurons|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11370
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LBX1 Expression in NALM6 Cells: -2.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>