======= LDHA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LDHA
  * **<color #00a2e8>Official Name</color>**: lactate dehydrogenase A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3939|3939]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00338|P00338]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LDHA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LDHA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/150000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldh 1 N|
|Ldh 1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-lactate dehydrogenase activity|
|lactate metabolic process|
|post-embryonic animal organ development|
|NAD binding|
|glycolytic process|
|ATP generation from ADP|
|NAD metabolic process|
|ADP metabolic process|
|nucleoside diphosphate phosphorylation|
|purine nucleoside diphosphate metabolic process|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|response to estrogen|
|nucleoside diphosphate metabolic process|
|kinase binding|
|response to cAMP|
|response to hydrogen peroxide|
|carbohydrate catabolic process|
|response to organophosphorus|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|response to purine-containing compound|
|response to carbohydrate|
|response to reactive oxygen species|
|ATP metabolic process|
|response to nutrient|
|response to antibiotic|
|cadherin binding|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|response to hypoxia|
|response to decreased oxygen levels|
|purine-containing compound metabolic process|
|response to oxygen levels|
|response to oxidative stress|
|generation of precursor metabolites and energy|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|response to nutrient levels|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|nucleobase-containing small molecule metabolic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|oxidation-reduction process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|response to nitrogen compound|
|response to abiotic stimulus|
|phosphorylation|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell death|
|small molecule metabolic process|
|organic substance catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.17|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.92|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LDHA Expression in NALM6 Cells: 9.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>