======= LEPR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LEPR
  * **<color #00a2e8>Official Name</color>**: leptin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3953|3953]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48357|P48357]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LEPR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LEPR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601007|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter- regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). {ECO:0000250|UniProtKB:P48356, ECO:0000269|PubMed:12504075, ECO:0000269|PubMed:22405007, ECO:0000269|PubMed:25060689, ECO:0000269|PubMed:8805376, ECO:0000269|PubMed:9537324, ECO:0000305|PubMed:25232147}. Isoform E: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. {ECO:0000250|UniProtKB:P48356}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lep receptor Ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leptin receptor activity|
|leptin-mediated signaling pathway|
|glial cell proliferation|
|negative regulation of gluconeogenesis|
|cellular response to leptin stimulus|
|response to leptin|
|regulation of feeding behavior|
|energy homeostasis|
|peptide hormone binding|
|cytokine binding|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of gluconeogenesis|
|bone growth|
|cytokine receptor activity|
|negative regulation of carbohydrate metabolic process|
|regulation of bone remodeling|
|glycogen metabolic process|
|cellular glucan metabolic process|
|glucan metabolic process|
|energy reserve metabolic process|
|regulation of behavior|
|regulation of tissue remodeling|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|negative regulation of autophagy|
|negative regulation of small molecule metabolic process|
|regulation of carbohydrate biosynthetic process|
|organ growth|
|positive regulation of cold-induced thermogenesis|
|regulation of glucose metabolic process|
|cholesterol metabolic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|T cell differentiation|
|transmembrane signaling receptor activity|
|regulation of cellular carbohydrate metabolic process|
|regulation of cold-induced thermogenesis|
|cellular carbohydrate metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|basolateral plasma membrane|
|receptor complex|
|regulation of carbohydrate metabolic process|
|gliogenesis|
|energy derivation by oxidation of organic compounds|
|T cell activation|
|lymphocyte differentiation|
|negative regulation of cellular catabolic process|
|steroid metabolic process|
|negative regulation of catabolic process|
|alcohol metabolic process|
|angiogenesis|
|multicellular organismal homeostasis|
|phagocytosis|
|leukocyte differentiation|
|regulation of autophagy|
|lymphocyte activation|
|developmental growth|
|growth|
|external side of plasma membrane|
|blood vessel morphogenesis|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|cell population proliferation|
|hemopoiesis|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|negative regulation of catalytic activity|
|sexual reproduction|
|regulation of cellular catabolic process|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|leukocyte activation|
|oxidation-reduction process|
|multi-organism reproductive process|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|identical protein binding|
|cell activation|
|response to cytokine|
|chemical homeostasis|
|negative regulation of molecular function|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|neurogenesis|
|homeostatic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.89|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.88|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.84|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.81|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.75|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17644
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LEPR Expression in NALM6 Cells: 2.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>