======= LGALS9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LGALS9
  * **<color #00a2e8>Official Name</color>**: galectin 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3965|3965]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00182|O00182]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LGALS9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LGALS9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601879|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gal-bind lectin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|disaccharide binding|
|regulation of activated T cell autonomous cell death|
|positive regulation of activated T cell autonomous cell death|
|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response|
|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response|
|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|
|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|
|natural killer cell tolerance induction|
|positive regulation of dendritic cell apoptotic process|
|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|
|positive regulation of interleukin-12 secretion|
|galactose binding|
|mature conventional dendritic cell differentiation|
|positive regulation of CD4-positive, alpha-beta T cell proliferation|
|positive regulation of interleukin-13 secretion|
|toll-like receptor 2 signaling pathway|
|positive regulation of dendritic cell differentiation|
|regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|
|galactoside binding|
|p38MAPK cascade|
|negative regulation of mast cell degranulation|
|positive regulation of interleukin-10 secretion|
|positive regulation of interferon-gamma secretion|
|regulation of interleukin-12 secretion|
|positive regulation of dendritic cell chemotaxis|
|negative regulation of CD4-positive, alpha-beta T cell proliferation|
|negative regulation of mast cell activation involved in immune response|
|positive regulation of viral entry into host cell|
|regulation of dendritic cell chemotaxis|
|regulation of interleukin-10 secretion|
|regulation of dendritic cell apoptotic process|
|regulation of interleukin-13 secretion|
|negative regulation of alpha-beta T cell proliferation|
|positive regulation of monocyte chemotactic protein-1 production|
|regulation of CD4-positive, alpha-beta T cell proliferation|
|negative regulation of myeloid leukocyte mediated immunity|
|regulation of interferon-gamma secretion|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|negative regulation of activated T cell proliferation|
|negative regulation of mast cell activation|
|regulation of dendritic cell differentiation|
|negative regulation of leukocyte degranulation|
|tolerance induction|
|positive regulation of T cell apoptotic process|
|negative regulation of natural killer cell mediated cytotoxicity|
|positive regulation of regulatory T cell differentiation|
|negative regulation of natural killer cell mediated immunity|
|positive regulation of interleukin-8 secretion|
|positive regulation of interleukin-13 production|
|regulation of monocyte chemotactic protein-1 production|
|regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|negative regulation of leukocyte mediated cytotoxicity|
|positive regulation of lymphocyte apoptotic process|
|positive regulation of alpha-beta T cell proliferation|
|negative regulation of chemokine production|
|positive regulation of transforming growth factor beta production|
|toll-like receptor 4 signaling pathway|
|positive regulation of tumor necrosis factor secretion|
|negative regulation of cell killing|
|regulation of interleukin-5 production|
|regulation of interleukin-13 production|
|positive regulation of interleukin-4 production|
|regulation of interleukin-8 secretion|
|negative regulation of regulated secretory pathway|
|regulation of interleukin-4 production|
|positive regulation of leukocyte apoptotic process|
|ERK1 and ERK2 cascade|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of tumor necrosis factor secretion|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of regulatory T cell differentiation|
|regulation of viral entry into host cell|
|regulation of alpha-beta T cell proliferation|
|positive regulation of interleukin-6 secretion|
|cellular response to virus|
|dendritic cell differentiation|
|negative regulation of interferon-gamma production|
|positive regulation of interleukin-1 beta secretion|
|regulation of T cell apoptotic process|
|negative regulation of exocytosis|
|regulation of mast cell degranulation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of interleukin-12 production|
|regulation of transforming growth factor beta production|
|regulation of mast cell activation involved in immune response|
|regulation of activated T cell proliferation|
|positive regulation of interleukin-10 production|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of alpha-beta T cell activation|
|positive regulation of interleukin-1 secretion|
|regulation of p38MAPK cascade|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of mast cell activation|
|regulation of natural killer cell mediated immunity|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-8 production|
|negative regulation of leukocyte mediated immunity|
|regulation of leukocyte degranulation|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-10 production|
|regulation of lymphocyte apoptotic process|
|regulation of interleukin-12 production|
|regulation of interleukin-1 secretion|
|positive regulation of chemokine production|
|negative regulation of innate immune response|
|positive regulation of interleukin-1 production|
|regulation of myeloid leukocyte mediated immunity|
|negative regulation of tumor necrosis factor production|
|regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of T cell proliferation|
|positive regulation of alpha-beta T cell activation|
|negative regulation of intracellular transport|
|positive regulation of viral life cycle|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|regulation of alpha-beta T cell differentiation|
|positive regulation of interferon-gamma production|
|maternal process involved in female pregnancy|
|regulation of interleukin-8 production|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of leukocyte mediated cytotoxicity|
|regulation of chemokine production|
|negative regulation of leukocyte proliferation|
|regulation of interleukin-1 beta production|
|positive regulation of T cell differentiation|
|regulation of leukocyte apoptotic process|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of leukocyte chemotaxis|
|regulation of alpha-beta T cell activation|
|negative regulation of response to biotic stimulus|
|positive regulation of lymphocyte differentiation|
|positive regulation of interleukin-6 production|
|regulation of interleukin-1 production|
|positive regulation of T cell proliferation|
|regulation of interferon-gamma production|
|toll-like receptor signaling pathway|
|regulation of cell killing|
|stress-activated MAPK cascade|
|positive regulation of viral process|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of T cell activation|
|myeloid leukocyte differentiation|
|regulation of leukocyte chemotaxis|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|pattern recognition receptor signaling pathway|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|stress-activated protein kinase signaling cascade|
|negative regulation of lymphocyte activation|
|regulation of viral life cycle|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of T cell proliferation|
|cellular response to interferon-gamma|
|regulation of regulated secretory pathway|
|regulation of lymphocyte differentiation|
|positive regulation of endopeptidase activity|
|carbohydrate binding|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|positive regulation of apoptotic signaling pathway|
|female pregnancy|
|response to interferon-gamma|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of hemopoiesis|
|positive regulation of peptidase activity|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|response to interleukin-1|
|positive regulation of T cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of viral process|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|multi-multicellular organism process|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|negative regulation of multi-organism process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|negative regulation of secretion|
|innate immune response-activating signal transduction|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|response to virus|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|positive regulation of innate immune response|
|enzyme binding|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|regulation of endopeptidase activity|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|negative regulation of immune system process|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|defense response to other organism|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.77|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.78|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.83|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8380
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LGALS9 Expression in NALM6 Cells: -0.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>