======= LHB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LHB
  * **<color #00a2e8>Official Name</color>**: luteinizing hormone subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3972|3972]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01229|P01229]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LHB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LHB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/152780|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cys knot|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|progesterone biosynthetic process|
|progesterone metabolic process|
|C21-steroid hormone biosynthetic process|
|C21-steroid hormone metabolic process|
|ketone biosynthetic process|
|peptide hormone processing|
|steroid hormone biosynthetic process|
|hormone biosynthetic process|
|cellular ketone metabolic process|
|hormone activity|
|Golgi lumen|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|male gonad development|
|development of primary male sexual characteristics|
|male sex differentiation|
|protein processing|
|hormone-mediated signaling pathway|
|hormone metabolic process|
|gonad development|
|development of primary sexual characteristics|
|protein maturation|
|steroid metabolic process|
|sex differentiation|
|signaling receptor binding|
|reproductive structure development|
|reproductive system development|
|drug metabolic process|
|peptide metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to hormone stimulus|
|developmental process involved in reproduction|
|cellular amide metabolic process|
|response to hormone|
|cell-cell signaling|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|proteolysis|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|extracellular space|
|small molecule metabolic process|
|extracellular region|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3863
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LHB Expression in NALM6 Cells: -2.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>