======= LILRB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LILRB1
  * **<color #00a2e8>Official Name</color>**: leukocyte immunoglobulin like receptor B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10859|10859]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NHL6|Q8NHL6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LILRB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LILRB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604811|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of gamma-delta T cell activation involved in immune response|
|negative regulation of interferon-beta secretion|
|positive regulation of gamma-delta T cell activation involved in immune response|
|HLA-A specific inhibitory MHC class I receptor activity|
|negative regulation of interleukin-10 secretion|
|HLA-B specific inhibitory MHC class I receptor activity|
|negative regulation of transforming growth factor-beta secretion|
|MHC class Ib protein complex binding|
|Fc receptor mediated inhibitory signaling pathway|
|negative regulation of interleukin-12 secretion|
|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|
|regulation of transforming growth factor-beta secretion|
|negative regulation of interferon-gamma biosynthetic process|
|MHC class Ib receptor activity|
|negative regulation of serotonin secretion|
|T cell proliferation involved in immune response|
|regulation of interferon-beta secretion|
|positive regulation of gamma-delta T cell activation|
|MHC class I receptor activity|
|negative regulation of osteoclast development|
|MHC class Ib protein binding|
|regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|
|negative regulation of CD8-positive, alpha-beta T cell activation|
|negative regulation of dendritic cell differentiation|
|negative regulation of cytokine secretion involved in immune response|
|immune response-inhibiting cell surface receptor signaling pathway|
|negative regulation of T cell mediated cytotoxicity|
|regulation of gamma-delta T cell activation|
|regulation of serotonin secretion|
|negative regulation of dendritic cell apoptotic process|
|negative regulation of tumor necrosis factor biosynthetic process|
|regulation of interleukin-12 secretion|
|immune response-inhibiting signal transduction|
|interferon-gamma secretion|
|positive regulation of macrophage cytokine production|
|regulation of interleukin-10 secretion|
|negative regulation of bone development|
|regulation of dendritic cell apoptotic process|
|positive regulation of cytolysis|
|regulation of osteoclast development|
|regulation of dendritic cell differentiation|
|negative regulation of interferon-beta production|
|regulation of macrophage cytokine production|
|negative regulation of natural killer cell mediated cytotoxicity|
|regulation of CD8-positive, alpha-beta T cell activation|
|negative regulation of natural killer cell mediated immunity|
|regulation of cytokine secretion involved in immune response|
|negative regulation of interleukin-12 production|
|regulation of cytolysis|
|regulation of interferon-gamma biosynthetic process|
|negative regulation of interleukin-10 production|
|negative regulation of leukocyte mediated cytotoxicity|
|interferon-gamma production|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|MHC class I protein binding|
|negative regulation of T cell mediated immunity|
|protein phosphatase 1 binding|
|negative regulation of cell killing|
|negative regulation of neurotransmitter transport|
|regulation of bone development|
|negative regulation of cytokine production involved in immune response|
|positive regulation of defense response to virus by host|
|negative regulation of osteoclast differentiation|
|regulation of tumor necrosis factor biosynthetic process|
|negative regulation of cytokine biosynthetic process|
|dendritic cell differentiation|
|negative regulation of interferon-gamma production|
|regulation of T cell mediated cytotoxicity|
|negative regulation of production of molecular mediator of immune response|
|SH2 domain binding|
|regulation of defense response to virus by host|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of alpha-beta T cell activation|
|T cell proliferation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of natural killer cell mediated cytotoxicity|
|negative regulation of endocytosis|
|regulation of natural killer cell mediated immunity|
|negative regulation of adaptive immune response|
|negative regulation of type I interferon production|
|negative regulation of myeloid leukocyte differentiation|
|negative regulation of leukocyte apoptotic process|
|regulation of interferon-beta production|
|cytokine secretion|
|negative regulation of leukocyte mediated immunity|
|regulation of interleukin-10 production|
|positive regulation of cytokine production involved in immune response|
|regulation of interleukin-12 production|
|negative regulation of innate immune response|
|negative regulation of tumor necrosis factor production|
|negative regulation of T cell proliferation|
|negative regulation of calcium ion transport|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|receptor internalization|
|T cell activation involved in immune response|
|regulation of osteoclast differentiation|
|negative regulation of cytokine secretion|
|regulation of T cell mediated immunity|
|regulation of defense response to virus|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of myeloid cell differentiation|
|regulation of leukocyte mediated cytotoxicity|
|negative regulation of leukocyte proliferation|
|amyloid-beta binding|
|regulation of leukocyte apoptotic process|
|lymphocyte proliferation|
|regulation of cytokine production involved in immune response|
|mononuclear cell proliferation|
|regulation of alpha-beta T cell activation|
|negative regulation of response to biotic stimulus|
|positive regulation of production of molecular mediator of immune response|
|leukocyte proliferation|
|regulation of interferon-gamma production|
|negative regulation of leukocyte differentiation|
|regulation of cell killing|
|receptor metabolic process|
|regulation of cytokine biosynthetic process|
|lymphocyte activation involved in immune response|
|negative regulation of T cell activation|
|regulation of myeloid leukocyte differentiation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of type I interferon production|
|negative regulation of protein secretion|
|negative regulation of hemopoiesis|
|negative regulation of peptide secretion|
|regulation of production of molecular mediator of immune response|
|regulation of neurotransmitter transport|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of ion transport|
|regulation of tumor necrosis factor production|
|negative regulation of immune response|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of adaptive immune response|
|protein localization to extracellular region|
|peptide secretion|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|negative regulation of protein transport|
|cellular response to lipopolysaccharide|
|negative regulation of establishment of protein localization|
|defense response to virus|
|cellular response to molecule of bacterial origin|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of endocytosis|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|negative regulation of multi-organism process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|negative regulation of secretion|
|T cell activation|
|receptor-mediated endocytosis|
|regulation of calcium ion transport|
|positive regulation of cell-cell adhesion|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|response to virus|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|negative regulation of cell development|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|regulation of metal ion transport|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of protein secretion|
|regulation of immune effector process|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|endocytosis|
|hemopoiesis|
|negative regulation of cell cycle|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|negative regulation of cell population proliferation|
|import into cell|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of secretion|
|response to lipid|
|positive regulation of immune response|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|negative regulation of cell death|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10617
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LILRB1 Expression in NALM6 Cells: 2.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>