======= LIN54 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIN54
  * **<color #00a2e8>Official Name</color>**: lin-54 DREAM MuvB core complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=132660|132660]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6MZP7|Q6MZP7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIN54&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIN54|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613367|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA- binding protein that binds the promoter of CDK1 in a sequence- specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258). {ECO:0000269|PubMed:17531812, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:19725879, ECO:0000269|PubMed:27465258}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CXC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of cell cycle|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.98|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.92|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.87|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.85|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.82|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.81|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.75|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.82|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.85|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.06|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2484
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIN54 Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>