======= LIPE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIPE
  * **<color #00a2e8>Official Name</color>**: lipase E, hormone sensitive type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3991|3991]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05469|Q05469]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIPE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIPE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151750|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 3|
|HSL N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hormone-sensitive lipase activity|
|diacylglycerol catabolic process|
|serine hydrolase activity|
|long-chain fatty acid catabolic process|
|triglyceride lipase activity|
|diacylglycerol metabolic process|
|triglyceride catabolic process|
|acylglycerol catabolic process|
|neutral lipid catabolic process|
|glycerolipid catabolic process|
|caveola|
|triglyceride metabolic process|
|lipid droplet|
|fatty acid catabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|long-chain fatty acid metabolic process|
|monocarboxylic acid catabolic process|
|cholesterol metabolic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|cellular lipid catabolic process|
|steroid metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|alcohol metabolic process|
|fatty acid metabolic process|
|glycerolipid metabolic process|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|protein kinase binding|
|monocarboxylic acid metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|protein phosphorylation|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|phosphorylation|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.7|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.473|
|[[:human genes:c:c14orf93|C14orf93]]|0.447|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.442|
|[[:human genes:k:kif3c|KIF3C]]|0.431|
|[[:human genes:c:cope|COPE]]|0.428|
|[[:human genes:r:rrp7a|RRP7A]]|0.426|
|[[:human genes:a:akirin2|AKIRIN2]]|0.424|
|[[:human genes:p:psap|PSAP]]|0.424|
|[[:human genes:o:orc1|ORC1]]|0.418|
|[[:human genes:v:vasn|VASN]]|0.418|
|[[:human genes:n:nup153|NUP153]]|0.413|
|[[:human genes:b:bysl|BYSL]]|0.412|
|[[:human genes:n:nup133|NUP133]]|0.41|
|[[:human genes:c:cbwd3|CBWD3]]|0.409|
|[[:human genes:s:slc4a1|SLC4A1]]|0.409|
|[[:human genes:c:cbwd5|CBWD5]]|0.407|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.406|
|[[:human genes:n:npipb5|NPIPB5]]|0.405|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.403|
|[[:human genes:p:psmc6|PSMC6]]|0.401|
|[[:human genes:r:ranbp2|RANBP2]]|0.401|
|[[:human genes:p:psmd11|PSMD11]]|0.401|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2794
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIPE Expression in NALM6 Cells: 3.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>