======= LMOD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LMOD3
  * **<color #00a2e8>Official Name</color>**: leiomodin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56203|56203]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q0VAK6|Q0VAK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LMOD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LMOD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616112|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the leiomodin family of proteins. This protein contains three actin-binding domains, a tropomyosin domain, a leucine-rich repeat domain, and a Wiskott-Aldrich syndrome protein homology 2 domain (WH2). Localization of this protein to the pointed ends of thin filaments has been observed, and there is evidence that this protein acts as a catalyst of actin nucleation, and is important to the organization of sarcomeric thin filaments in skeletal muscles. Mutations in this gene have been associated as one cause of Nemaline myopathy, as other genes have also been linked to this disorder. Nemaline myopathy is a disorder characterized by nonprogressive generalized muscle weakness and protein inclusions (nemaline bodies) in skeletal myofibers. Patients with mutations in this gene often present with a severe congenital form of the disorder. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25250574). Increases the rate of actin polymerization (PubMed:25250574). {ECO:0000269|PubMed:25250574}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tropomodulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pointed-end actin filament capping|
|positive regulation of skeletal muscle fiber development|
|regulation of skeletal muscle fiber development|
|skeletal muscle thin filament assembly|
|tropomyosin binding|
|skeletal myofibril assembly|
|striated muscle thin filament|
|skeletal muscle fiber development|
|positive regulation of skeletal muscle tissue development|
|myotube cell development|
|actin monomer binding|
|M band|
|myofibril|
|actin nucleation|
|positive regulation of myotube differentiation|
|actin filament capping|
|negative regulation of actin filament depolymerization|
|regulation of skeletal muscle tissue development|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|regulation of myotube differentiation|
|myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|muscle fiber development|
|negative regulation of protein depolymerization|
|myofibril assembly|
|negative regulation of protein polymerization|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|negative regulation of protein complex disassembly|
|regulation of protein depolymerization|
|positive regulation of muscle cell differentiation|
|positive regulation of actin filament polymerization|
|regulation of striated muscle cell differentiation|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|regulation of protein complex disassembly|
|actomyosin structure organization|
|skeletal muscle tissue development|
|positive regulation of protein polymerization|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|regulation of muscle tissue development|
|striated muscle cell development|
|regulation of muscle organ development|
|negative regulation of cytoskeleton organization|
|muscle cell development|
|regulation of muscle cell differentiation|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|striated muscle cell differentiation|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|muscle cell differentiation|
|positive regulation of protein complex assembly|
|muscle contraction|
|regulation of actin filament organization|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|actin filament-based process|
|positive regulation of organelle organization|
|negative regulation of cellular component organization|
|organelle assembly|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.99|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.82|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.8|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.72|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.8|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12582
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LMOD3 Expression in NALM6 Cells: 2.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>