======= LMX1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LMX1B
  * **<color #00a2e8>Official Name</color>**: LIM homeobox transcription factor 1 beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4010|4010]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60663|O60663]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LMX1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LMX1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602575|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dopaminergic neuron differentiation|
|dorsal/ventral pattern formation|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regionalization|
|in utero embryonic development|
|pattern specification process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|DNA-binding transcription factor activity|
|embryo development|
|neuron differentiation|
|positive regulation of transcription by RNA polymerase II|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.02|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-2|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.82|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.75|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.7|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.78|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.82|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.85|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.92|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2253
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LMX1B Expression in NALM6 Cells: 2.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>