======= LPAR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LPAR1
  * **<color #00a2e8>Official Name</color>**: lysophosphatidic acid receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1902|1902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92633|Q92633]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LPAR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LPAR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602282|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). {ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:9070858, ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to 1-oleoyl-sn-glycerol 3-phosphate|
|cellular response to 1-oleoyl-sn-glycerol 3-phosphate|
|lysophosphatidic acid receptor activity|
|positive regulation of smooth muscle cell chemotaxis|
|lysophosphatidic acid binding|
|regulation of smooth muscle cell chemotaxis|
|bleb assembly|
|optic nerve development|
|corpus callosum development|
|negative regulation of cAMP-mediated signaling|
|G-protein alpha-subunit binding|
|positive regulation of Rho protein signal transduction|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|activation of phospholipase C activity|
|dendritic shaft|
|positive regulation of smooth muscle cell migration|
|oligodendrocyte development|
|positive regulation of phospholipase C activity|
|positive regulation of dendritic spine development|
|regulation of phospholipase C activity|
|regulation of cAMP-mediated signaling|
|cranial nerve development|
|positive regulation of stress fiber assembly|
|endocytic vesicle|
|positive regulation of phospholipase activity|
|regulation of smooth muscle cell migration|
|positive regulation of actin filament bundle assembly|
|positive regulation of Ras protein signal transduction|
|oligodendrocyte differentiation|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|positive regulation of small GTPase mediated signal transduction|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|nerve development|
|regulation of stress fiber assembly|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|PDZ domain binding|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of lipase activity|
|cerebellum development|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|metencephalon development|
|response to organophosphorus|
|positive regulation of chemotaxis|
|regulation of Rho protein signal transduction|
|dendritic spine|
|regulation of dendrite development|
|hindbrain development|
|regulation of cell shape|
|negative regulation of neuron projection development|
|activation of MAPK activity|
|glial cell differentiation|
|negative regulation of cell projection organization|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of supramolecular fiber organization|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cell chemotaxis|
|regulation of chemotaxis|
|gliogenesis|
|cellular response to oxygen levels|
|positive regulation of cytoskeleton organization|
|negative regulation of neuron differentiation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of Ras protein signal transduction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|telencephalon development|
|regulation of actin filament organization|
|positive regulation of MAP kinase activity|
|endosome|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|negative regulation of cell development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|positive regulation of neuron differentiation|
|neuronal cell body|
|response to oxygen levels|
|positive regulation of cell projection organization|
|forebrain development|
|regulation of actin filament-based process|
|cellular calcium ion homeostasis|
|plasma membrane bounded cell projection assembly|
|calcium ion homeostasis|
|cell projection assembly|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cellular metal ion homeostasis|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|cell surface|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|brain development|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|head development|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.83|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.71|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7810
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LPAR1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>