======= LPL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LPL
  * **<color #00a2e8>Official Name</color>**: lipoprotein lipase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4023|4023]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06858|P06858]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LPL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LPL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609708|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL) (PubMed:27578112). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). {ECO:0000250, ECO:0000269|PubMed:11342582, ECO:0000269|PubMed:27578112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipase|
|Abhydrolase 6|
|PLAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|triglyceride binding|
|lipoprotein lipase activity|
|low-density lipoprotein particle mediated signaling|
|lipoprotein particle mediated signaling|
|positive regulation of chemokine (C-C motif) ligand 2 secretion|
|regulation of chemokine (C-C motif) ligand 2 secretion|
|positive regulation of cholesterol storage|
|positive regulation of sequestering of triglyceride|
|lipoprotein particle binding|
|chylomicron remodeling|
|positive regulation of chemokine (C-X-C motif) ligand 2 production|
|very-low-density lipoprotein particle remodeling|
|regulation of chemokine (C-X-C motif) ligand 2 production|
|regulation of sequestering of triglyceride|
|chylomicron|
|protein membrane anchor|
|triglyceride-rich lipoprotein particle remodeling|
|positive regulation of chemokine secretion|
|regulation of cholesterol storage|
|apolipoprotein binding|
|heparan sulfate proteoglycan binding|
|regulation of chemokine secretion|
|positive regulation of macrophage derived foam cell differentiation|
|phospholipase activity|
|high-density lipoprotein particle remodeling|
|cellular response to low-density lipoprotein particle stimulus|
|triglyceride biosynthetic process|
|very-low-density lipoprotein particle|
|positive regulation of tumor necrosis factor secretion|
|positive regulation of lipid storage|
|regulation of lipoprotein lipase activity|
|neutral lipid biosynthetic process|
|acylglycerol biosynthetic process|
|triglyceride lipase activity|
|lipase activity|
|triglyceride catabolic process|
|response to lipoprotein particle|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|cellular response to lipoprotein particle stimulus|
|protein-containing complex remodeling|
|regulation of tumor necrosis factor secretion|
|regulation of macrophage derived foam cell differentiation|
|positive regulation of interleukin-6 secretion|
|positive regulation of interleukin-1 beta secretion|
|triglyceride homeostasis|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|acylglycerol homeostasis|
|negative regulation of cellular response to insulin stimulus|
|positive regulation of interleukin-1 secretion|
|plasma lipoprotein particle organization|
|regulation of lipid storage|
|regulation of interleukin-1 beta secretion|
|protein-lipid complex subunit organization|
|response to cold|
|positive regulation of interleukin-1 beta production|
|glycerolipid catabolic process|
|regulation of interleukin-1 secretion|
|cellular response to fatty acid|
|positive regulation of chemokine production|
|positive regulation of interleukin-1 production|
|positive regulation of fat cell differentiation|
|cellular response to nutrient|
|regulation of plasma lipoprotein particle levels|
|regulation of cellular response to insulin stimulus|
|triglyceride metabolic process|
|regulation of chemokine production|
|cholesterol homeostasis|
|sterol homeostasis|
|regulation of interleukin-1 beta production|
|positive regulation of lipid localization|
|response to fatty acid|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of interleukin-1 production|
|positive regulation of interleukin-6 production|
|regulation of lipase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|fatty acid biosynthetic process|
|terpenoid metabolic process|
|regulation of fat cell differentiation|
|lipid homeostasis|
|regulation of lipid localization|
|isoprenoid metabolic process|
|response to glucose|
|positive regulation of cytokine secretion|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|response to hexose|
|regulation of tumor necrosis factor production|
|response to monosaccharide|
|regulation of tumor necrosis factor superfamily cytokine production|
|heparin binding|
|response to carbohydrate|
|response to temperature stimulus|
|monocarboxylic acid biosynthetic process|
|cellular lipid catabolic process|
|regulation of cytokine secretion|
|cellular response to acid chemical|
|response to nutrient|
|glycerolipid biosynthetic process|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|cellular response to external stimulus|
|signaling receptor binding|
|regulation of inflammatory response|
|response to acid chemical|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of peptide secretion|
|response to nutrient levels|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|positive regulation of response to external stimulus|
|cell surface|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|response to lipid|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|positive regulation of transport|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|response to abiotic stimulus|
|lipid metabolic process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15581
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LPL Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>