======= LRP10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRP10
  * **<color #00a2e8>Official Name</color>**: LDL receptor related protein 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26020|26020]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z4F1|Q7Z4F1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRP10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRP10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609921|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldl recept a|
|CUB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|low-density lipoprotein particle receptor activity|
|clathrin-coated pit|
|inner ear development|
|ear development|
|lipid transport|
|lipid localization|
|sensory organ development|
|endocytosis|
|import into cell|
|lipid metabolic process|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.61|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.59|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.43|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.31|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.1|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.04|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.86|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.84|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.77|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.76|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.76|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.75|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.75|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.72|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.7|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.72|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.39|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17237
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRP10 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>