======= LRP8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRP8
  * **<color #00a2e8>Official Name</color>**: LDL receptor related protein 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7804|7804]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14114|Q14114]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRP8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRP8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). {ECO:0000250|UniProtKB:Q924X6, ECO:0000269|PubMed:12807892, ECO:0000269|PubMed:12899622, ECO:0000269|PubMed:12950167}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cEGF|
|Ldl recept a|
|Ldl recept b|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ammon gyrus development|
|reelin receptor activity|
|very-low-density lipoprotein particle receptor activity|
|reelin-mediated signaling pathway|
|high-density lipoprotein particle binding|
|low-density lipoprotein particle receptor activity|
|cargo receptor activity|
|apolipoprotein binding|
|cellular response to cholesterol|
|positive regulation of CREB transcription factor activity|
|positive regulation of dendritic spine morphogenesis|
|cellular response to sterol|
|response to cholesterol|
|response to sterol|
|microtubule associated complex|
|positive regulation of dendrite morphogenesis|
|kinesin binding|
|positive regulation of dendritic spine development|
|regulation of dendritic spine morphogenesis|
|positive regulation of protein tyrosine kinase activity|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|caveola|
|hippocampus development|
|cellular response to alcohol|
|regulation of protein tyrosine kinase activity|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|retinoid metabolic process|
|limbic system development|
|diterpenoid metabolic process|
|cerebral cortex development|
|terpenoid metabolic process|
|transmembrane signaling receptor activity|
|isoprenoid metabolic process|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|pallium development|
|positive regulation of peptidyl-tyrosine phosphorylation|
|receptor complex|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|response to alcohol|
|regulation of peptidyl-tyrosine phosphorylation|
|postsynaptic density|
|telencephalon development|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of neuron projection development|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|positive regulation of neuron differentiation|
|neuronal cell body|
|positive regulation of cell projection organization|
|forebrain development|
|dendrite|
|regulation of DNA-binding transcription factor activity|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of innate immune response|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|endocytosis|
|positive regulation of kinase activity|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|calcium ion binding|
|brain development|
|regulation of defense response|
|regulation of multi-organism process|
|head development|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|response to lipid|
|regulation of kinase activity|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|proteolysis|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-4.32|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-3.48|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.91|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.56|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.43|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-2.23|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.93|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.93|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.86|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.75|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.79|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gclm|GCLM]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15601
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRP8 Expression in NALM6 Cells: 8.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>