======= LRPAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRPAP1
  * **<color #00a2e8>Official Name</color>**: LDL receptor related protein associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4043|4043]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30533|P30533]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRPAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRPAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104225|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:7774585}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Alpha-2-MRAP C|
|Alpha-2-MRAP N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rough endoplasmic reticulum lumen|
|regulation of very-low-density lipoprotein particle clearance|
|very-low-density lipoprotein particle receptor binding|
|negative regulation of very-low-density lipoprotein particle clearance|
|lipase binding|
|amyloid-beta clearance by transcytosis|
|positive regulation of amyloid-beta clearance|
|negative regulation of lipoprotein particle clearance|
|negative regulation of amyloid-beta clearance|
|extracellular negative regulation of signal transduction|
|extracellular regulation of signal transduction|
|negative regulation of receptor internalization|
|regulation of amyloid-beta clearance|
|endosome lumen|
|transcytosis|
|regulation of lipoprotein particle clearance|
|low-density lipoprotein particle receptor binding|
|amyloid-beta clearance|
|negative regulation of receptor-mediated endocytosis|
|receptor antagonist activity|
|negative regulation of endocytosis|
|regulation of receptor internalization|
|negative regulation of signaling receptor activity|
|cis-Golgi network|
|endoplasmic reticulum-Golgi intermediate compartment|
|amyloid-beta binding|
|regulation of receptor-mediated endocytosis|
|Golgi lumen|
|negative regulation of protein binding|
|negative regulation of binding|
|heparin binding|
|regulation of signaling receptor activity|
|regulation of endocytosis|
|regulation of protein binding|
|endosome|
|signaling receptor binding|
|regulation of binding|
|negative regulation of transport|
|regulation of vesicle-mediated transport|
|cell surface|
|negative regulation of cellular component organization|
|Golgi apparatus|
|negative regulation of cell death|
|endoplasmic reticulum|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.78|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.77|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14027
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRPAP1 Expression in NALM6 Cells: 6.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>