======= LRRC30 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRRC30
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat containing 30
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=339291|339291]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NM36|A6NM36]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRRC30&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRRC30|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|photoreceptor outer segment membrane|
|photoreceptor inner segment|
|protein serine/threonine phosphatase activity|
|protein dephosphorylation|
|dephosphorylation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.86|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.78|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.71|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.97|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|2.1|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.14|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.18|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|2.24|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.38|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.43|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.429|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10994
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRRC30 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>