======= LRRC32 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRRC32
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat containing 32
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2615|2615]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14392|Q14392]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRRC32&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRRC32|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137207|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transforming growth factor beta3 activation|
|regulation of transforming growth factor beta3 production|
|regulation of transforming growth factor beta activation|
|negative regulation of activated T cell proliferation|
|transforming growth factor beta binding|
|secondary palate development|
|regulation of transforming growth factor beta production|
|regulation of activated T cell proliferation|
|negative regulation of T cell proliferation|
|negative regulation of cytokine secretion|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|roof of mouth development|
|transforming growth factor beta receptor signaling pathway|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|negative regulation of lymphocyte activation|
|cellular response to transforming growth factor beta stimulus|
|regulation of T cell proliferation|
|response to transforming growth factor beta|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of cell activation|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|negative regulation of secretion|
|extracellular matrix|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|cellular response to growth factor stimulus|
|regulation of lymphocyte activation|
|response to growth factor|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of protein localization|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|integral component of plasma membrane|
|response to endogenous stimulus|
|extracellular space|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.1|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.9|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12087
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRRC32 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>