======= LRRC7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRRC7
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57554|57554]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96NW7|Q96NW7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRRC7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRRC7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614453|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269|PubMed:11729199}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotransmitter receptor transport postsynaptic membrane to endosome|
|protein localization to early endosome|
|neurotransmitter receptor transport, endosome to plasma membrane|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|endosome to plasma membrane protein transport|
|protein localization to endosome|
|ionotropic glutamate receptor complex|
|neurotransmitter receptor transport to postsynaptic membrane|
|neurotransmitter receptor transport to plasma membrane|
|establishment of protein localization to postsynaptic membrane|
|axon initial segment|
|retrograde transport, endosome to plasma membrane|
|ionotropic glutamate receptor binding|
|neurotransmitter receptor transport|
|protein localization to postsynaptic membrane|
|regulation of NMDA receptor activity|
|receptor localization to synapse|
|establishment or maintenance of epithelial cell apical/basal polarity|
|receptor clustering|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|establishment of protein localization to plasma membrane|
|specific granule lumen|
|protein localization to synapse|
|regulation of glutamate receptor signaling pathway|
|regulation of neurotransmitter receptor activity|
|localization within membrane|
|vesicle-mediated transport to the plasma membrane|
|cell-cell adherens junction|
|cell-cell junction|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|protein localization to plasma membrane|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|postsynaptic membrane|
|endosomal transport|
|protein localization to cell periphery|
|postsynaptic density|
|protein-containing complex localization|
|regulation of ion transmembrane transporter activity|
|establishment of protein localization to membrane|
|regulation of transmembrane transporter activity|
|synapse|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|neuron projection|
|regulation of cation transmembrane transport|
|positive regulation of neuron differentiation|
|MAPK cascade|
|positive regulation of cell projection organization|
|signal transduction by protein phosphorylation|
|establishment of protein localization to organelle|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulated exocytosis|
|regulation of cell projection organization|
|protein localization to organelle|
|leukocyte mediated immunity|
|exocytosis|
|regulation of neurogenesis|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|protein phosphorylation|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of cellular component organization|
|phosphorylation|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.75|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17393
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRRC7 Expression in NALM6 Cells: 3.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>