======= LSS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LSS
  * **<color #00a2e8>Official Name</color>**: lanosterol synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4047|4047]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48449|P48449]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LSS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LSS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600909|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. {ECO:0000269|PubMed:26200341, ECO:0000269|PubMed:7639730}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prenyltrans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lanosterol synthase activity|
|triterpenoid biosynthetic process|
|beta-amyrin synthase activity|
|triterpenoid metabolic process|
|terpenoid biosynthetic process|
|isoprenoid biosynthetic process|
|cholesterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of sterol biosynthetic process|
|sterol biosynthetic process|
|regulation of cholesterol metabolic process|
|regulation of alcohol biosynthetic process|
|lipid droplet|
|regulation of steroid biosynthetic process|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|terpenoid metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|isoprenoid metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|steroid metabolic process|
|regulation of protein stability|
|alcohol metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|organic hydroxy compound metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.02|
|[[:results:exp302|35°C R06 exp302]]|-1.87|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.79|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.77|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.72|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5823
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LSS Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>