======= LTBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LTBP2
  * **<color #00a2e8>Official Name</color>**: latent transforming growth factor beta binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4053|4053]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14767|Q14767]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LTBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LTBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602091|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play an integral structural role in elastic-fiber architectural organization and/or assembly.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF CA|
|cEGF|
|TB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microfibril binding|
|growth factor binding|
|cell|
|transforming growth factor beta receptor signaling pathway|
|extracellular matrix structural constituent|
|cellular response to transforming growth factor beta stimulus|
|protein secretion|
|establishment of protein localization to extracellular region|
|response to transforming growth factor beta|
|protein localization to extracellular region|
|heparin binding|
|peptide secretion|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|extracellular matrix|
|protein targeting|
|collagen-containing extracellular matrix|
|supramolecular fiber organization|
|cellular response to growth factor stimulus|
|response to growth factor|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|secretion|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|extracellular space|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3909
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LTBP2 Expression in NALM6 Cells: 0.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>