======= LTBP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LTBP3
  * **<color #00a2e8>Official Name</color>**: latent transforming growth factor beta binding protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4054|4054]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NS15|Q9NS15]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LTBP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LTBP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cEGF|
|TB|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mesenchymal stem cell proliferation|
|transforming growth factor beta activation|
|regulation of mesenchymal stem cell proliferation|
|transforming growth factor beta production|
|positive regulation of mesenchymal stem cell differentiation|
|regulation of mesenchymal stem cell differentiation|
|lung saccule development|
|positive regulation of bone remodeling|
|positive regulation of bone resorption|
|negative regulation of bone mineralization|
|positive regulation of stem cell differentiation|
|transforming growth factor beta binding|
|negative regulation of chondrocyte differentiation|
|negative regulation of biomineralization|
|negative regulation of biomineral tissue development|
|negative regulation of cartilage development|
|positive regulation of tissue remodeling|
|positive regulation of stem cell proliferation|
|regulation of bone resorption|
|lung alveolus development|
|bone remodeling|
|regulation of bone remodeling|
|regulation of chondrocyte differentiation|
|regulation of stem cell proliferation|
|regulation of cartilage development|
|regulation of tissue remodeling|
|negative regulation of ossification|
|regulation of bone mineralization|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|tissue remodeling|
|transforming growth factor beta receptor signaling pathway|
|bone morphogenesis|
|regulation of stem cell differentiation|
|cytokine production|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|lung development|
|respiratory tube development|
|regulation of ossification|
|respiratory system development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|skeletal system morphogenesis|
|collagen-containing extracellular matrix|
|skeletal system development|
|cellular response to growth factor stimulus|
|response to growth factor|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|tube development|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6389
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LTBP3 Expression in NALM6 Cells: 3.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>