======= LTBP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LTBP4
  * **<color #00a2e8>Official Name</color>**: latent transforming growth factor beta binding protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8425|8425]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N2S1|Q8N2S1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LTBP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LTBP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604710|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM) (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF CA|
|cEGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|growth hormone secretion|
|transforming growth factor beta-activated receptor activity|
|transforming growth factor beta binding|
|glycosaminoglycan binding|
|peptide hormone secretion|
|hormone secretion|
|hormone transport|
|transforming growth factor beta receptor signaling pathway|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|integrin binding|
|extracellular matrix structural constituent|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|signal release|
|peptide secretion|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|protein folding|
|extracellular matrix|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|collagen-containing extracellular matrix|
|regulation of cell growth|
|cellular response to growth factor stimulus|
|response to growth factor|
|regulation of hormone levels|
|regulation of growth|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|regulation of proteolysis|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|peptide transport|
|amide transport|
|extracellular space|
|regulation of cell differentiation|
|nitrogen compound transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.74|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.79|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.89|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.03|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17583
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LTBP4 Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>