======= LZTR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LZTR1
  * **<color #00a2e8>Official Name</color>**: leucine zipper like transcription regulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8216|8216]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N653|Q8N653]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LZTR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LZTR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600574|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable transcriptional regulator that may play a crucial role in embryogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
|Kelch 1|
|Kelch 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ras GTPase binding|
|Cul3-RING ubiquitin ligase complex|
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|endomembrane system|
|recycling endosome membrane|
|regulation of Ras protein signal transduction|
|regulation of small GTPase mediated signal transduction|
|negative regulation of intracellular signal transduction|
|DNA-binding transcription factor activity|
|protein ubiquitination|
|protein modification by small protein conjugation|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.65|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.9|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.84|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.72|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.73|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.76|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.84|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.84|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.84|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.16|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.26|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.48|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.7|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.96|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|4.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kctd5|KCTD5]]|0.485|
|[[:human genes:n:nf1|NF1]]|0.458|
|[[:human genes:d:dusp6|DUSP6]]|0.454|
|[[:human genes:r:rasa2|RASA2]]|0.423|
|[[:human genes:s:spred2|SPRED2]]|0.422|
|[[:human genes:r:rfwd2|RFWD2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16910
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LZTR1 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>