======= LZTS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LZTS2
  * **<color #00a2e8>Official Name</color>**: leucine zipper tumor suppressor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84445|84445]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRK4|Q9BRK4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LZTS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LZTS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610454|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fez1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|primary ureteric bud growth|
|ureteric bud elongation|
|ureter morphogenesis|
|spindle midzone assembly|
|microtubule severing|
|ureter development|
|negative regulation of protein localization to nucleus|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|mitotic cytokinesis|
|nephron tubule development|
|renal tubule development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|mesonephros development|
|nephron epithelium development|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|spindle assembly|
|negative regulation of cellular protein localization|
|developmental growth involved in morphogenesis|
|regulation of protein localization to nucleus|
|nephron development|
|kidney epithelium development|
|vesicle|
|spindle organization|
|midbody|
|nuclear export|
|negative regulation of canonical Wnt signaling pathway|
|negative regulation of Wnt signaling pathway|
|nucleocytoplasmic transport|
|nuclear transport|
|kidney development|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|epithelial tube morphogenesis|
|microtubule|
|urogenital system development|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|developmental growth|
|growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|regulation of cellular protein localization|
|tissue morphogenesis|
|mitotic cell cycle process|
|tube morphogenesis|
|microtubule-based process|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|organelle assembly|
|tube development|
|regulation of cellular localization|
|animal organ morphogenesis|
|cell cycle process|
|regulation of protein localization|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|negative regulation of signal transduction|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|intracellular transport|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|tissue development|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16120
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LZTS2 Expression in NALM6 Cells: 4.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>