======= MAD2L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAD2L1
  * **<color #00a2e8>Official Name</color>**: mitotic arrest deficient 2 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4085|4085]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13257|Q13257]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAD2L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAD2L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601467|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. {ECO:0000269|PubMed:10700282, ECO:0000269|PubMed:11804586, ECO:0000269|PubMed:15024386}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HORMA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitotic cell cycle spindle assembly checkpoint|
|positive regulation of spindle checkpoint|
|positive regulation of cell cycle checkpoint|
|establishment of centrosome localization|
|negative regulation of ubiquitin protein ligase activity|
|nuclear pore nuclear basket|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|regulation of spindle checkpoint|
|regulation of mitotic spindle checkpoint|
|negative regulation of ubiquitin-protein transferase activity|
|spindle checkpoint|
|mitotic spindle assembly checkpoint|
|regulation of ubiquitin protein ligase activity|
|spindle assembly checkpoint|
|mitotic spindle checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|centrosome localization|
|establishment of mitotic spindle orientation|
|microtubule organizing center localization|
|negative regulation of mitotic sister chromatid segregation|
|regulation of cell cycle checkpoint|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|negative regulation of mitotic nuclear division|
|establishment of spindle localization|
|negative regulation of nuclear division|
|spindle localization|
|regulation of ubiquitin-protein transferase activity|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|negative regulation of protein ubiquitination|
|mitotic spindle|
|regulation of sister chromatid segregation|
|anaphase-promoting complex-dependent catabolic process|
|negative regulation of protein modification by small protein conjugation or removal|
|kinetochore|
|condensed chromosome kinetochore|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|establishment of cell polarity|
|spindle pole|
|chromosome|
|negative regulation of protein catabolic process|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of mitotic nuclear division|
|protein C-terminus binding|
|regulation of nuclear division|
|cell cycle checkpoint|
|establishment or maintenance of cell polarity|
|regulation of protein ubiquitination|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|chromosome segregation|
|negative regulation of transferase activity|
|nuclear division|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|establishment of organelle localization|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of cell cycle|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|protein catabolic process|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|regulation of transferase activity|
|negative regulation of cell death|
|regulation of catabolic process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|identical protein binding|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|regulation of cell cycle|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.28|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.13|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.99|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.9|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.83|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.81|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.8|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.74|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.74|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.73|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.72|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.72|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.95|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.02|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.36|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.96|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|3.89|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|4.02|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|4.08|
|[[:results:exp17|DABN 20μM R00 exp17]]|4.79|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|5.07|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|5.14|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|5.24|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|5.62|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|5.66|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|5.87|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|5.89|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|6.04|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|6.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mad1l1|MAD1L1]]|0.863|
|[[:human genes:r:rbm14|RBM14]]|0.816|
|[[:human genes:k:kntc1|KNTC1]]|0.803|
|[[:human genes:b:bub1b|BUB1B]]|0.799|
|[[:human genes:b:bub3|BUB3]]|0.799|
|[[:human genes:z:zw10|ZW10]]|0.788|
|[[:human genes:t:trip13|TRIP13]]|0.728|
|[[:human genes:z:zwilch|ZWILCH]]|0.718|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.65|
|[[:human genes:f:fnta|FNTA]]|0.544|
|[[:human genes:m:med16|MED16]]|0.505|
|[[:human genes:f:fntb|FNTB]]|0.489|
|[[:human genes:s:srp72|SRP72]]|0.48|
|[[:human genes:p:pelo|PELO]]|0.478|
|[[:human genes:r:rnmt|RNMT]]|0.477|
|[[:human genes:d:dpagt1|DPAGT1]]|0.469|
|[[:human genes:s:spcs2|SPCS2]]|0.465|
|[[:human genes:d:dbr1|DBR1]]|0.46|
|[[:human genes:d:ddx20|DDX20]]|0.453|
|[[:human genes:c:cdc20|CDC20]]|0.452|
|[[:human genes:t:tmem41b|TMEM41B]]|0.43|
|[[:human genes:p:polr3h|POLR3H]]|0.43|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.425|
|[[:human genes:r:rtcb|RTCB]]|0.422|
|[[:human genes:t:timm22|TIMM22]]|0.42|
|[[:human genes:g:gemin5|GEMIN5]]|0.418|
|[[:human genes:d:dctn6|DCTN6]]|0.41|
|[[:human genes:g:gnb1l|GNB1L]]|0.409|
|[[:human genes:m:mars|MARS]]|0.409|
|[[:human genes:h:hbs1l|HBS1L]]|0.407|
|[[:human genes:t:tbca|TBCA]]|0.406|
|[[:human genes:s:slc35b1|SLC35B1]]|0.406|
|[[:human genes:h:hmgb2|HMGB2]]|0.403|
|[[:human genes:r:rttn|RTTN]]|0.402|
|[[:human genes:m:med18|MED18]]|0.401|
|[[:human genes:e:eif4e|EIF4E]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 182/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|3/28|
|bone|3/26|
|breast|7/33|
|central nervous system|14/56|
|cervix|3/4|
|colorectal|5/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|4/21|
|liver|4/20|
|lung|20/75|
|lymphocyte|5/16|
|ovary|5/26|
|pancreas|7/24|
|peripheral nervous system|8/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|12/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1010
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAD2L1 Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>