======= MADCAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MADCAM1
  * **<color #00a2e8>Official Name</color>**: mucosal vascular addressin cell adhesion molecule 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8174|8174]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13477|Q13477]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MADCAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MADCAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102670|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Adhes-Ig like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin binding involved in cell-matrix adhesion|
|leukocyte tethering or rolling|
|leukocyte adhesion to vascular endothelial cell|
|heterotypic cell-cell adhesion|
|positive regulation of lymphocyte migration|
|cellular extravasation|
|receptor clustering|
|leukocyte cell-cell adhesion|
|regulation of lymphocyte migration|
|localization within membrane|
|integrin-mediated signaling pathway|
|cell-matrix adhesion|
|positive regulation of leukocyte migration|
|cell-substrate adhesion|
|regulation of leukocyte migration|
|extracellular matrix organization|
|leukocyte migration|
|extracellular structure organization|
|protein localization to membrane|
|positive regulation of cell migration|
|cell-cell adhesion|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cell motility|
|localization of cell|
|positive regulation of immune system process|
|regulation of immune response|
|locomotion|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of immune system process|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.596|
|[[:human genes:s:s1pr4|S1PR4]]|0.529|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.524|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.515|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.508|
|[[:human genes:t:tfip11|TFIP11]]|0.487|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.487|
|[[:human genes:d:ddtl|DDTL]]|0.487|
|[[:human genes:m:mt1e|MT1E]]|0.486|
|[[:human genes:v:vasn|VASN]]|0.482|
|[[:human genes:c:chd4|CHD4]]|0.482|
|[[:human genes:k:kctd17|KCTD17]]|0.482|
|[[:human genes:d:dtl|DTL]]|0.48|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.477|
|[[:human genes:t:tceb3c|TCEB3C]]|0.476|
|[[:human genes:p:prim1|PRIM1]]|0.474|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.472|
|[[:human genes:r:rps2|RPS2]]|0.464|
|[[:human genes:n:nupl1|NUPL1]]|0.463|
|[[:human genes:o:orc1|ORC1]]|0.463|
|[[:human genes:r:rps12|RPS12]]|0.459|
|[[:human genes:c:cope|COPE]]|0.455|
|[[:human genes:p:psma6|PSMA6]]|0.454|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.45|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.45|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.45|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.45|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.45|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.449|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.448|
|[[:human genes:s:shpk|SHPK]]|0.447|
|[[:human genes:a:akirin2|AKIRIN2]]|0.444|
|[[:human genes:p:psma7|PSMA7]]|0.444|
|[[:human genes:c:col2a1|COL2A1]]|0.439|
|[[:human genes:p:prpf4|PRPF4]]|0.438|
|[[:human genes:a:aaas|AAAS]]|0.435|
|[[:human genes:c:cln6|CLN6]]|0.435|
|[[:human genes:c:cbwd5|CBWD5]]|0.433|
|[[:human genes:v:vps28|VPS28]]|0.426|
|[[:human genes:c:cactin|CACTIN]]|0.425|
|[[:human genes:c:cbwd3|CBWD3]]|0.424|
|[[:human genes:c:cdc73|CDC73]]|0.424|
|[[:human genes:s:syt9|SYT9]]|0.424|
|[[:human genes:m:mepce|MEPCE]]|0.423|
|[[:human genes:c:cgb2|CGB2]]|0.422|
|[[:human genes:m:myt1l|MYT1L]]|0.421|
|[[:human genes:m:mcoln1|MCOLN1]]|0.42|
|[[:human genes:t:twistnb|TWISTNB]]|0.418|
|[[:human genes:t:tspy8|TSPY8]]|0.418|
|[[:human genes:p:psmd1|PSMD1]]|0.418|
|[[:human genes:p:pcf11|PCF11]]|0.416|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.416|
|[[:human genes:s:ssh2|SSH2]]|0.413|
|[[:human genes:t:terf1|TERF1]]|0.411|
|[[:human genes:l:lad1|LAD1]]|0.411|
|[[:human genes:t:timeless|TIMELESS]]|0.411|
|[[:human genes:l:lrr1|LRR1]]|0.41|
|[[:human genes:s:supt5h|SUPT5H]]|0.409|
|[[:human genes:p:psmb4|PSMB4]]|0.408|
|[[:human genes:c:ccdc116|CCDC116]]|0.408|
|[[:human genes:r:rplp2|RPLP2]]|0.407|
|[[:human genes:e:exosc5|EXOSC5]]|0.407|
|[[:human genes:n:nup133|NUP133]]|0.406|
|[[:human genes:a:acat1|ACAT1]]|0.406|
|[[:human genes:p:psmd14|PSMD14]]|0.403|
|[[:human genes:t:traip|TRAIP]]|0.402|
|[[:human genes:t:trim52|TRIM52]]|0.401|
|[[:human genes:c:crnkl1|CRNKL1]]|0.4|
|[[:human genes:r:rplp1|RPLP1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2330
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MADCAM1 Expression in NALM6 Cells: -1.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>